Exposing the Unique Connection between Metabolism and Virulence in Staphylococcus aureus  Andy Weiss, Renee M. Fleeman, Lindsey N. Shaw  Cell Chemical Biology  Volume 23, Issue 11, Pages 1317-1319 (November 2016) DOI: 10.1016/j.chembiol.2016.11.003 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 Proposed Model for ′882 Mechanism of Action and the Resulting Cellular Effects The negative effects of ′882 were shown to not only be dependent on oxygen availability (e.g., respiration versus fermentation), but also on the activity of energy consuming processes, such as SaeRS-dependent virulence factor production. Cell Chemical Biology 2016 23, 1317-1319DOI: (10.1016/j.chembiol.2016.11.003) Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 2 Experimental Workflow for Deriving the ′882 Mechanism of Action The red font indicates primary findings, while the blue and red boxes indicate primary and secondary validation experiments, respectively. The outcome of a given experiment is noted under the corresponding boxes. Unless otherwise stated, experiments were performed in the S. aureus NM background. Cell Chemical Biology 2016 23, 1317-1319DOI: (10.1016/j.chembiol.2016.11.003) Copyright © 2016 Elsevier Ltd Terms and Conditions