Figure 2 Lipid metabolism and metabolism-disrupting chemicals.

Slides:

Advertisements

Similar presentations

Adipose Tissue - Fed State

Advertisements

Lipogenesis Fats not only obtained from the diet but also obtained from lipogenesis in the body. Lipogenesis means synthesis of fats from CHO and proteins.

Physiological role of insulin Release of insulin by beta cells –Response to elevated blood glucose level –Effects of insulin Somewhat global Major effects.

Metabolic effects of Insulin and Glucagon Metabolism in the Well fed state Metabolism in the Starvation and Diabetes Mellitus Integration of Metabolism.

Lipogenesis Fats not only obtained from the diet but also obtained from lipogenesis in the body. Lipogenesis means synthesis of neutral fats (TAG) from.

Metabolic Syndrome: Focused on AMPK as Molecular Target for Metabolic Syndrome Bayu Lestari.

Hepatic Steatosis Chen-Yu Wang

Fatty Acid Metabolism 1. Fatty acid synthesis.

Hormonal regulation of lipid metabolism

Endocrine Block Glucose Homeostasis Dr. Usman Ghani.

Unit 1 Lesson 6 Activity 3- Insulin and the Human Body

The Endocrine Pancreas

Samir Parekh, Frank A. Anania Gastroenterology

Fat catabolism: generation of energy by fatty acid oxidation

Figure 2 Pathophysiology of hyperglycaemia in T2DM

Figure 1 Pathophysiological aspects of insulin

Figure 1 Candidate signalling pathways of irisin in adipocytes

Figure 5 Sterol regulatory element-binding

Metabolic Diseases Lesson 2.3

Figure 1 Immune cell metabolism during homeostasis

Nat. Rev. Endocrinol. doi: /nrendo

Nat. Rev. Nephrol. doi: /nrneph

Figure 2 Metabolic reprogramming of immune cells upon activation

Figure 3 Candidate signalling pathways of irisin in hepatocytes

Samir Parekh, Frank A. Anania Gastroenterology

Adipose tissue and reproduction in women

Figure 3 ER stress and hepatic steatosis: a vicious cycle

Figure 3 Polysaccharides from plants and mushrooms

Figure 4 Altered metabolism in chondrocytes in osteoarthritis

Figure 4 Effects of irisin on glucose homeostasis

Figure 2 Intracellular actions of metformin

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 1 Control of hepatic gluconeogenesis

Figure 2 Molecular mechanisms of the antidiabetic

UV Modulation of Subcutaneous Fat Metabolism

Volume 134, Issue 2, Pages (February 2008)

NASH: a mitochondrial disease

ChREBP in NASH – A liver transcription factor comes in from the cold

Ludger Scheja, Joerg Heeren Journal of Hepatology

Nat. Rev. Endocrinol. doi: /nrendo

Nat. Rev. Endocrinol. doi: /nrendo

Figure 2 BMPs in brown and beige adipogenesis and function

Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk Jennifer H. Stern, Joseph M. Rutkowski,

Figure 1 Key mechanistic pathways involved in the gut–liver axis in NAFLD progression Figure 1 | Key mechanistic pathways involved in the gut–liver axis.

Figure 6 Possible therapeutic targets to decrease hepatic steatosis

Figure 1 Regulation of hepatic glucose metabolism by the gut, brain and liver Figure 1 | Regulation of hepatic glucose metabolism by the gut, brain and.

Cristoforo Silvestri, Vincenzo Di Marzo Cell Metabolism

An Emerging Role of mTOR in Lipid Biosynthesis

Volume 134, Issue 4, Pages (April 2008)

Sweet Sixteenth for ChREBP: Established Roles and Future Goals

Volume 16, Issue 11, Pages (November 2008)

Nat. Rev. Endocrinol. doi: /nrendo

The genetics of alcohol dependence and alcohol-related liver disease

Figure 3 Regulation of insulin sensitivity by innate immune cells

Konstantinos G. Michalakis, M.D., James H. Segars, M.D.

Conserved Metabolic Regulatory Functions of Sirtuins

Russell K. Soon, Jim S. Yan, James P. Grenert, Jacquelyn J. Maher

Adipogenesis and Obesity: Rounding Out the Big Picture

Varman T. Samuel, Gerald I. Shulman Cell Metabolism

Insulin Resistance in the Defense against Obesity

Nat. Rev. Endocrinol. doi: /nrendo

Knockdown of MPST weakens JNK phosphorylation, ameliorates hepatic oxidative stress and suppresses the release of MCP-1. Knockdown of MPST weakens JNK.

Mechanisms for Insulin Resistance: Common Threads and Missing Links

Adel Hammoutene, Pierre-Emmanuel Rautou Journal of Hepatology

Lipid Metabolism Greases the Stem Cell Engine

The Salt-Inducible Kinases: Emerging Metabolic Regulators

The Endocrine Pancreas

Figure 1 Thyroid hormone effects on hepatic lipid metabolism

The multifaceted role of mTORC1 in the control of lipid metabolism

Presentation transcript:

Figure 2 Lipid metabolism and metabolism-disrupting chemicals. Figure 2 | Lipid metabolism and metabolism-disrupting chemicals. In β cells, metabolism-disrupting chemicals (MDCs) might decrease or increase insulin production, which affects hepatic lipogenesis following the upregulation or downregulation of levels of sterol regulatory element-binding protein 1 isoform C (SREBP1C) and subsequently those of acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1). MDCs might have a direct impact on the liver by affecting the mitochondrial respiratory chain (MRC) or by directly regulating the expression of lipogenic enzymes. If lipogenesis is increased, lipids accumulate in the liver and are transported through the blood to adipocytes where they are captured and stored. Alterations in insulin signalling affect lipogenesis in adipocytes, and MDCs directly alter lipogenesis and adipogenesis in white adipose tissue. The disrupted function of adipocytes is manifested by alterations in leptin and adiponectin signalling, as well as disturbed IL-6, IL-1β and tumour necrosis factor (TNF) secretion. These alterations increase the probability of developing metabolic disorders. FABP, fatty acid-binding protein; FAT, fatty acid translocase; FATP, fatty acid transport protein; GLUT2, glucose transporter type 2, liver; G6P, glucose-6-phosphate; Glycerol-3P, glycerol 3-phosphate; IR, insulin receptor; NAFLD, nonalcoholic fatty liver disease; TCA, tricarboxylic acid; VLDL, very low-density lipoprotein. Permission obtained from Cristina Sala-Ripoll, Alicante, Spain. Nadal, A. et al. (2017) Endocrine-disrupting chemicals and the regulation of energy balance Nat. Rev. Endocrinol. doi:10.1038/nrendo.2017.51