Increased ICAM-1 expression in aortic disease

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Presentation transcript:

Increased ICAM-1 expression in aortic disease Cornelius A. Davis, MD, William H. Pearce, MD, G.Kenneth Haines, MD, Manisha Shah, BS, Alisa E. Koch, MD Journal of Vascular Surgery Volume 18, Issue 5, Pages 875-880 (November 1993) DOI: 10.1016/0741-5214(93)90344-L Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Inflammatory cell infiltrate score (error bars represent standard error) assessed for aortic wall sections from cadaveric control group (normal) (n = 5), AOD group (n = 6), and AAA group (includes both inflammatory and noninflammatory aneurysms, n = 9). Journal of Vascular Surgery 1993 18, 875-880DOI: (10.1016/0741-5214(93)90344-L) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Immunohistochemical reactivity of frozen aortic tissue sections immunostained with anti-ICAM-1 monoclonal antibody (AA6). A, NAAA shows reactivity of large muscular vasa vasorum with anti-ICAM-1 (arrow) (Original magnification × 557.) B, AOD displays minimal endothelial reactivity with anti-ICAM-1 (arrow) (Original magnification × 557.) C, NL aortic tissue section shows definition of medial and intimal aortic layers by internal elastic lamina (Original magnification × 348.) D, High power view of vasa vasorum in NL aortic tissue shows minimal reactivity with anti-ICAM-1 (Original magnification × 696.) Journal of Vascular Surgery 1993 18, 875-880DOI: (10.1016/0741-5214(93)90344-L) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Percentage of vasa endothelial cells express ICAM-1 (error bars represent standard error) within investigated vascular disease groups: normal cadaveric controls, AOD, NAAA, and IAAA. Asterisk represents significant difference (p < 0.05) from control group. IAAA group (n = 3) was too small for meaningful statistical comparison. Journal of Vascular Surgery 1993 18, 875-880DOI: (10.1016/0741-5214(93)90344-L) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Percentage of vasa endothelial cells express VCAM-1 within investigated vascular disease groups: normal cadaveric controls, AOD, AAA, IAAA (error bars represent standard error). Trend toward increased expression in AOD and AAA groups did not reach statistical significance. Journal of Vascular Surgery 1993 18, 875-880DOI: (10.1016/0741-5214(93)90344-L) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 Percentage of vasa endothelial cells express E-selectin within investigated vascular disease groups: normal cadaveric controls, AOD, AAA, IAAA (error bars represent standard error). Trend toward increased expression in AOD and IAAA groups did not reach statistical significance. Journal of Vascular Surgery 1993 18, 875-880DOI: (10.1016/0741-5214(93)90344-L) Copyright © 1993 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions