Volume 72, Issue 12, Pages (December 2007)

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Volume 72, Issue 12, Pages 1423-1426 (December 2007) Thiazide diuretic monotherapy for hypertension: Diuretic's dark side just got darker B.H. Rovin, L.A. Hebert Kidney International Volume 72, Issue 12, Pages 1423-1426 (December 2007) DOI: 10.1038/sj.ki.5002656 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Association of BP reduction with risk reduction for fatal and non-fatal myocardial infarction in randomized trials of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) against a comparator therapy (diuretic, β-blocker, or calcium channel blocker). The fitted lines represent the summary meta-regressions for the outcomes of the ACEI trials (lower line) and the ARB trials (upper line). See Boxes 1, 2, and 3 for further analysis. The ACEI trials' meta-regression line can be regarded as the 'optimal ACEI therapy' line, because all trials, except ALLHAT, used ACEI optimally (with diuretic, if needed). (Adapted from ref. 8.) Kidney International 2007 72, 1423-1426DOI: (10.1038/sj.ki.5002656) Copyright © 2007 International Society of Nephrology Terms and Conditions