Compromised cerebral blood flow reactivity is a predictor of stroke in patients with symptomatic carotid artery occlusive disease Marshall W. Webster,

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Presentation transcript:

Compromised cerebral blood flow reactivity is a predictor of stroke in patients with symptomatic carotid artery occlusive disease Marshall W. Webster, MD, Michel S. Makaroun, MD, David L. Steed, MD, Holly A. Smith, BS, David W. Johnson, MD, Howard Yonas, MD Journal of Vascular Surgery Volume 21, Issue 2, Pages 338-345 (February 1995) DOI: 10.1016/S0741-5214(95)70274-1 Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Xenon/CT CBF study. A and C represent regular baseline CT images for density comparison and anatomic correlation. Blood flow maps prior to and after the administration of ACZ are shown in B and D respectively. After ACZ, CBF is reduced primarily in the right middle cerebral artery territory. Color key shows CBF in cc/100gm/min. Numbers in B and D indicate mean CBF values in the relevant regions of interest (circled areas). (Reproduced with permission from Yonas et al. J Neurosurg 1993;79:484.) Journal of Vascular Surgery 1995 21, 338-345DOI: (10.1016/S0741-5214(95)70274-1) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Cumulative stroke free survival by life table method for Groups I and II. p = 0.0004. Journal of Vascular Surgery 1995 21, 338-345DOI: (10.1016/S0741-5214(95)70274-1) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 CBF values in cc/100gm/min for each of the 95 patients depicted before and after ACZ challenge in the territory of least reactivity. Points above (to the left) of the line represent patients who had no drop in CBF. Points below (to the right) of the line represent patients with a decrease in CBF in one or more territories. Patients who sustained a stroke are depicted with a closed symbol. Patients who remain asymptomatic are depicted with open symbols. Journal of Vascular Surgery 1995 21, 338-345DOI: (10.1016/S0741-5214(95)70274-1) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions