Volume 7, Issue 2, Pages (July 2000)

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Volume 7, Issue 2, Pages 121-125 (July 2000) Alternate magnetic fields potentiate monoamine oxidase activity in the brain Isao Yokoi, Hideaki Kabuto, Yukiko Nanba, Nihei Yamamoto, Norio Ogawa, Akitane Mori Pathophysiology Volume 7, Issue 2, Pages 121-125 (July 2000) DOI: 10.1016/S0928-4680(00)00038-9

Fig. 1 Schematic figure of a magnetic field generator and an incubation bath. Magnetic field was generated using a Helmholtz coil operated by a programmable bipolar power supply controlled with a computer. The magnetic field was monitored using a Gauss-meter and a synchroscope. Pathophysiology 2000 7, 121-125DOI: (10.1016/S0928-4680(00)00038-9)

Fig. 2 Effect of static magnetic fields on monoamine oxidase (MAO)-A activity. Though rat brain homogenate was incubated with 10 μM of serotonin for 20 min with 15 min preincubation, MAO-A activity was not changed. Abscissa; power of static magnetic field (mT), ordinate, % change in MAO activity (in 30 μT of static magnetic field as 100%), and bars represent S.E.M. (N=6). Pathophysiology 2000 7, 121-125DOI: (10.1016/S0928-4680(00)00038-9)

Fig. 3 Effect of alternate isosceles triangular magnetic fields (AITMF) on monoamine oxidase (MAO)-A activity. Rat brain homogenate was incubated with 10 μM of serotonin for 20 min with 15 min preincubation. MAO-A activity was not changed. Abscissa; power of AITMF (mT/s), ordinate; % change in MAO activity (in 30 μT as 100%) and bars represent S.E.M. (N=7). Pathophysiology 2000 7, 121-125DOI: (10.1016/S0928-4680(00)00038-9)

Fig. 4 Effect of static magnetic fields on monoamine oxidase (MAO)-B activity. Rat brain homogenate was incubated with 500 μM of m-nitrobenzylamine (m-NBz) for 45 min with 15 min preincubation. MAO-B activity was not changed. Abscissa; power of static magnetic field (mT), ordinate, % change in MAO activity (in 30 μT of static magnetic field as 100%), and bars represent S.E.M. (N=6–10). Pathophysiology 2000 7, 121-125DOI: (10.1016/S0928-4680(00)00038-9)

Fig. 5 Effect of alternate isosceles triangular magnetic fields (AITMF) on monoamine oxidase (MAO)-B activity. Rat brain homogenate was incubated with 60 μM of m-nitrobenzylamine (m-NBz) for 45 min with 15 min preincubation. MAO-B activity was 86.0±5.5 pmol m-NBz formation/mg protein per min (mean±S.E.M., N=12). MAO-B activity incubated in 100 mT/s was significantly increased (P<0.025). Abscissa; power of AITMF (mT/s), ordinate; % change in AMO activity (in 30 μT of static magnetic field as 100%), and bars represent S.E.M. (experimental number in parentheses). Pathophysiology 2000 7, 121-125DOI: (10.1016/S0928-4680(00)00038-9)

Fig. 6 Monoamine oxidase (MAO)-B activity in 100 mT/s of alternate isosceles triangular magnetic field (AITMF). The figure shows the Linweaver–Burke plot, and bars represent S.E.M. Closed circles indicated that brain homogenate was incubated with 20–500 μM of m-nitrobenzylamine (m-NBz) for 45 min with 15 min preincubation in 100 mT/s of AITMF, and open circles indicated control incubations performed in 30 μT of static magnetic field. Michaelis’ constant (Km) and maximal velocity (Vmax) in the control incubations were 130.6±4.0 pmol m-NBz formation/mg protein per min (pmol/mg per min) and 68.5±2.3 μM (mean±S.E.M., N=7), respectively. In AITMF, these were 145.1±3.8 pmol/mg per min and 49.3±3.4 μM (N=7), respectively. Changes in Vmax and Km were significant. Decrease in Km indicated the increase in the affinity of the substrate to the enzyme in 100 mT/s of AITMF. Pathophysiology 2000 7, 121-125DOI: (10.1016/S0928-4680(00)00038-9)