LV-powered coronary sinus retroperfusion reduces infarct size in acutely ischemic pigs Jeffrey S Martin, MD, John G Byrne, MD, Olivier Y Ghez, MD, Umer.

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LV-powered coronary sinus retroperfusion reduces infarct size in acutely ischemic pigs Jeffrey S Martin, MD, John G Byrne, MD, Olivier Y Ghez, MD, Umer Sayeed-Shah, MD, Sergey D Grachev, MD, Rita G Laurence, BS, Lawrence H Cohn, MD The Annals of Thoracic Surgery Volume 69, Issue 1, Pages 84-89 (January 2000) DOI: 10.1016/S0003-4975(99)00865-6

Fig 1 Left ventricle to coronary sinus shunt (LVCSS). (CS = coronary sinus; LV = left ventricle; RV = right ventricle; SVC = superior vena cava.) The Annals of Thoracic Surgery 2000 69, 84-89DOI: (10.1016/S0003-4975(99)00865-6)

Fig 2 Mean coronary sinus pressure. ∗p < 0.01 versus other groups. (LVCSS = left ventricle to coronary sinus shunt; LVCSS/PCSO = left ventricle to coronary sinus shunt with partial coronary sinus occlusion.) The Annals of Thoracic Surgery 2000 69, 84-89DOI: (10.1016/S0003-4975(99)00865-6)

Fig 3 (A) Ischemic zone segmental shortening. No significant difference among groups at any time point. (B) Nonischemic zone segmental shortening. No significant difference among groups at any time point. (LVCSS = left ventricle to coronary sinus shunt; LVCSS/PCSO = left ventricle to coronary sinus shunt with partial coronary sinus occlusion; PreO = preocclusion; PostO = postocclusion; 30min = 30 minutes occlusion; 1hrR = 1 hour reperfusion.) The Annals of Thoracic Surgery 2000 69, 84-89DOI: (10.1016/S0003-4975(99)00865-6)

Fig 4 (A) Area at risk. No significant difference among groups. (B) Area of necrosis. ∗p < 0.01 versus controls; †p < 0.01 versus LVCSS. (LVCSS = left ventricle to coronary sinus shunt; LVCSS/PCSO = left ventricle to coronary sinus shunt with partial coronary sinus occlusion.) The Annals of Thoracic Surgery 2000 69, 84-89DOI: (10.1016/S0003-4975(99)00865-6)

Fig 5 (A) Ischemic zone regional myocardial blood flow. ∗p < 0.05 versus PreO, PostO vs LVCSS/PCSO not significantly different; (B) Nonischemic zone regional myocardial blood flow. No significant difference. (LVCSS/PCSO = left ventricle to coronary sinus shunt with partial coronary sinus occlusion; PostO = postocclusion; PreO = preocclusion.) The Annals of Thoracic Surgery 2000 69, 84-89DOI: (10.1016/S0003-4975(99)00865-6)