Parallel evolution of coding sequences above neutral expectation.

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Parallel evolution of coding sequences above neutral expectation. Parallel evolution of coding sequences above neutral expectation. (A) Mutation frequency per gene observed in the CC17 population (black) in relation to the average substitution rate across the COH1 reference genome (blue line). Red dots correspond to the 152 genes with a statistically significant (P < 0.05, exact Poisson test) mutational bias compared to a neutral model of evolution (Table S2). (B) Venn diagram depicting the proportion of genes with a significant mutational signature across CC17, CC1, CC19, and CC23. (C) Functional classification of the 152 significant genes in CC17, based on the eggNOG database (24). Fold change corresponds to the proportional difference in the number of genes among those with a mutational bias compared to the COH1 coding sequences (in parentheses). Statistical significance was assessed with a Fisher exact test. *, P < 0.05; **, P < 0.01. Alexandre Almeida et al. mSystems 2017; doi:10.1128/mSystems.00074-17