Fig. 1. Map showing the study catchment area in the East of England.

Slides:



Advertisements
Similar presentations
Deep Sequencing of Patient Genomes for Disease Diagnosis: When Will It Become Routine? by Stephen F. Kingsmore, and Carol J. Saunders Sci Transl Med Volume.
Advertisements

First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip by Robert Farra, Norman F. Sheppard, Laura McCabe, Robert M. Neer, James M. Anderson,
Fig. 4 Careers and their Q parameter.
Fig. 1 CSF1 is increased in blood of melanoma patients and correlates with disease progression. CSF1 is increased in blood of melanoma patients and correlates.
Fig. 1. NS1 protein alignment and linear epitope mapping of the 10 antibodies used to run the DENV serotype–specific NS1 rapid tests, pan-DENV NS1 test,
Fig. 2. Effects of AZD4785 on proliferation and MAPK pathway signaling in KRAS mutant and wild-type cancer cells in vitro. Effects of AZD4785 on proliferation.
Fig. 2 LYM attractor metagene.
Fig. 6. dAST directly from clinical samples using dPCR and dLAMP for quantification. dAST directly from clinical samples using dPCR and dLAMP for quantification.
Fig. 4 Bacterial taxonomic groups that discriminate among RYGB-, SHAM-, and WMS-derived samples. Bacterial taxonomic groups that discriminate among RYGB-,
Fig. 8. Gene and protein changes in ALK-dependent STING pathways in human sepsis. Gene and protein changes in ALK-dependent STING pathways in human sepsis.
Fig. 3. Antimicrobial activity is detected in diverse strains of CoNS and not predictable at the species level. Antimicrobial activity is detected in diverse.
Fig. 5. Correlation of tail and long bone growth velocities with Cxm serum concentrations in mice. Correlation of tail and long bone growth velocities.
Fig. 4. Liver HBV mRNA paired-end sequencing reads in HBeAg-positive and HBeAg-negative chimpanzees. Liver HBV mRNA paired-end sequencing reads in HBeAg-positive.
Fig. 4. Biomechanical properties of treated tibiae.
Fig. 4. Functional annotation of VUS in EGFR.
Fig. 2. Associations between bacterial taxa abundance ascertained by fecal shotgun metagenomic sequencing and the fecal metabolome in healthy pediatric.
Fig. 1 Crohn’s disease association within the LRRK2 locus.
Fig. 2 TLR8 is aberrantly expressed on pDCs from SSc patients.
Fig. 3. Frequencies of amino acids at critical PGT121 and contact sites in the SHIV-SF162P3 challenge stock. Frequencies of amino acids at critical.
Fig. 6 Bimodal treatment results in reduced tinnitus loudness and reduced TFI scores in human patients. Bimodal treatment results in reduced tinnitus loudness.
Fig. 2. Response to repeat dosing of chimpanzees with ARC-520.
Fig. 4 Topical application of SAAP-148 ointment eradicates acute and established infections of MRSA and A. baumannii from the skin. Topical application.
Fig. 2. GPC3 expression in normal and tumor tissues.
Bio-AMS enhances the activity of rifampicin and ethambutol in vitro
Fig. 2. GDF15 crystal structure and enabled design of GDF15 molecules.
Increased ADMA in pregnancy is associated with SGA birth outcomes
Fig. 6. Effects of CD31-NP targeting in perfused human kidneys.
Fig. 4. Specific versus nonspecific NP accumulation.
Fig. 5. Vascularization of human liver seed grafts.
Dot plots of trisomic versus fetal fractions for cohorts 1 and 2
Fig. 5. In vivo characterization of adipogenesis by CT.
Fig. 6. Epitope mapping of C12G6.
Fig. 4. MATE1 transcription in RCC.
Fig. 2 STED microscopy of isolated cardiomyocytes from mice treated with MP-rhodamine–loaded CaPs. STED microscopy of isolated cardiomyocytes from mice.
Fig. 3 ROC curves of mCCNA1 and mVIM assayed in esophageal cytology brushings from control normal-appearing GE junctions versus BE and EAC cases. ROC curves.
Fig. 6 ROC curves of mCCNA1 and mVIM assayed on esophageal balloon samplings of the distal esophagus. ROC curves of mCCNA1 and mVIM assayed on esophageal.
Fig. 2. Best model fits. Best model fits. Illustration of the best model fits for the (A) basic, (B) continuous, and (C) cluster models. See Table 1 and.
Fig. 5. MasSpec Pen analysis of an HGSC tissue sample with mixed histologic composition. MasSpec Pen analysis of an HGSC tissue sample with mixed histologic.
Fig. 5 Hypoxic tumors from obese mice associate with increased production of IL-6 by adipocytes and myeloid cells. Hypoxic tumors from obese mice associate.
Fig. 4. Actin polymerization rhythms are required for circadian regulation of adhesion and wound-healing efficacy by fibroblasts. Actin polymerization.
Fig. 1. Experimental workflow of the dAST method and computationally estimated operational space. Experimental workflow of the dAST method and computationally.
Persistence of CAR4 cells is reduced after sustained TCR engagement
Fig. 7 Human study design for device testing.
Fig. 3. Recovery of AVP-deficient rats from anemia induced by sublethal irradiation. Recovery of AVP-deficient rats from anemia induced by sublethal irradiation.
Fig. 2. Pathways differentially regulated in patients with early Lyme disease and STARI. Pathways differentially regulated in patients with early Lyme.
Fig. 7. Gait training session overground with MGA or on a treadmill with upward support. Gait training session overground with MGA or on a treadmill with.
Fig. 3. The effects of DCA on hemodynamic and functional end points and their association with genetic factors (variants of the SIRT3 and UCP2 genes) that.
Workflow of a sample-to-answer AST performed in less than 30 min
Fig. 7 CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα. CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα.
Fig. 1 A single amino acid difference in the ATP-binding domain of GSK3α and GSK3β results in structural and topological differences. A single amino acid.
Fig. 2 Analysis of CLL lymph nodes.
Fig. 3 Rank stability of final models.
Fig. 3. TKI sensitivity assessed by the MANO method.
Fig. 4. The effect of single-dose rozanolixizumab on the concentration of IgG subtypes in healthy subjects. The effect of single-dose rozanolixizumab on.
Fig. 6. Analysis of SHIV-325c V1V2 envelope sequences in breakthrough infections. Analysis of SHIV-325c V1V2 envelope sequences in breakthrough infections.
Fig. 4. Exemplars of two patterns of nosocomial MRSA spread.
CD facilitates RCT in vivo and promotes urinary cholesterol excretion
Fig. 6. CXM correlates with age and growth velocity.
Fig. 5. Mapping of HBV S transcripts from HBeAg-positive and HBeAg-negative chimpanzees. Mapping of HBV S transcripts from HBeAg-positive and HBeAg-negative.
Fig. 7 Analysis of the bacterial nidus within tissue abscesses by MALDI IMS demonstrates a paucity of calprotectin signal. Analysis of the bacterial nidus.
Decreased weight and adiposity is transmissible via the gut microbiota
Fig. 7 Vaccine-induced influenza-specific B cells are not maintained in peripheral blood. Vaccine-induced influenza-specific B cells are not maintained.
Fig. 3 Activation of freshly isolated CD4+ T cells from HIV-infected patients on ART selectively reverses baseline blocks to splicing, elongation, and.
Fig. 5 Early and modest immune response at day 3 after exposure in Delayed animals. Early and modest immune response at day 3 after exposure in Delayed.
Fig. 4. Clearance of 12-mer-1 from a nonhuman primate model.
Fig. 5 Wireless, full-body pressure mapping on a human subject in a hospital bed. Wireless, full-body pressure mapping on a human subject in a hospital.
Fig. 5. Rises in RSV PRNT during the surveillance period.
Fig. 2 Time-resolved THz reflectivity from MAPI after band-edge optical excitation. Time-resolved THz reflectivity from MAPI after band-edge optical excitation.
Fig. 3 Local Maraba treatment of TNBC tumors provides long-term systemic protection. Local Maraba treatment of TNBC tumors provides long-term systemic.
Fig. 6. Connectivity and mobility maps for Lesotho.
Presentation transcript:

Fig. 1. Map showing the study catchment area in the East of England. Map showing the study catchment area in the East of England. The locations of hospitals (n = 3), GP practices (n = 75), and postcode districts are shown for the 1465 study cases. Postcode districts are color-coded to show the number of MRSA-positive cases sampled in each district. A total of 5,012,137 residents lived in the highlighted districts (16,240 km2) according to the 2011 UK Census. Francesc Coll et al., Sci Transl Med 2017;9:eaak9745 Published by AAAS