Hidekazu Itamura, M. D. , Takero Shindo, M. D. , Ph. D

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Presentation transcript:

The MEK Inhibitor Trametinib Selectively Suppresses GVHD, While Sparing GVT Effects Hidekazu Itamura, M.D., Takero Shindo, M.D., Ph.D., Isao Tawara, M.D., Ph.D., Ryusho Kariya, M.S., Seiji Okada, M.D., Ph.D., Krishna V. Komanduri, M.D., Shinya Kimura, M.D., Ph.D. Biology of Blood and Marrow Transplantation Volume 21, Issue 2, Pages S333-S334 (February 2015) DOI: 10.1016/j.bbmt.2014.11.532 Copyright © 2015 Terms and Conditions

Figure 1 Trametinib suppresses GVHD in the BDF1 model Biology of Blood and Marrow Transplantation 2015 21, S333-S334DOI: (10.1016/j.bbmt.2014.11.532) Copyright © 2015 Terms and Conditions

Figure 2 Peripheral blood T cells of BDF1-GVHD mice show increased phosphorylation of ERK, which is suppressed by Trametinib Biology of Blood and Marrow Transplantation 2015 21, S333-S334DOI: (10.1016/j.bbmt.2014.11.532) Copyright © 2015 Terms and Conditions

Figure 3 Trametinib spares GVT effects Biology of Blood and Marrow Transplantation 2015 21, S333-S334DOI: (10.1016/j.bbmt.2014.11.532) Copyright © 2015 Terms and Conditions