Successful rapid rituximab desensitization in an adolescent patient with nephrotic syndrome: Increase in number of Treg cells after desensitization Metin.

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Presentation transcript:

Successful rapid rituximab desensitization in an adolescent patient with nephrotic syndrome: Increase in number of Treg cells after desensitization Metin Aydogan, MD, Nail Yologlu, MD, Gulcin Gacar, PhD, Zeynep Seda Uyan, MD, Isil Eser, MD, Erdal Karaoz, PhD Journal of Allergy and Clinical Immunology Volume 132, Issue 2, Pages 478-480 (August 2013) DOI: 10.1016/j.jaci.2013.02.004 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 FACS plots show the quantitative change in CD4+CD25+ and CD4CD25FoxP3 Treg cells before desensitization, after first desensitization, and after last desentisization, respectively. A, Desensitization effect on the number of lymphocytes and monocytes detected by CFSE. R1, R2, and R3 refer to gated lymphocytes. M1, M2, and M3 refer to gated monocytes. B, An increase in CD4+CD25+ cells. C, An increase in CD4CD25FoxP3 cells. CFSE, Carboxyfluorescein diacetate, succinimidyl ester; FACS, fluorescence-activated cell sorting; FSC, forward scatter; PE, phycoerythrin; SSC, side scatter. Journal of Allergy and Clinical Immunology 2013 132, 478-480DOI: (10.1016/j.jaci.2013.02.004) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions