Sang Hong Lee, Naomi R. Wray, Michael E. Goddard, Peter M. Visscher

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Estimating Missing Heritability for Disease from Genome-wide Association Studies Sang Hong Lee, Naomi R. Wray, Michael E. Goddard, Peter M. Visscher The American Journal of Human Genetics Volume 88, Issue 3, Pages 294-305 (March 2011) DOI: 10.1016/j.ajhg.2011.02.002 Copyright © 2011 The American Society of Human Genetics Terms and Conditions

Figure 1 The Liability Threshold Model for a Disease Prevalence of K An underlying continuous random variable determines disease status. If liability exceeds the threshold t, then individuals are affected. The American Journal of Human Genetics 2011 88, 294-305DOI: (10.1016/j.ajhg.2011.02.002) Copyright © 2011 The American Society of Human Genetics Terms and Conditions

Figure 2 The Distribution of Liability When Cases Are Oversampled as in a Case-Control Study The American Journal of Human Genetics 2011 88, 294-305DOI: (10.1016/j.ajhg.2011.02.002) Copyright © 2011 The American Society of Human Genetics Terms and Conditions