Volume 379, Issue 9834, Pages (June 2012)

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Volume 379, Issue 9834, Pages 2364-2372 (June 2012) Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis Prof Joanna M Wardlaw, MD, Prof Veronica Murray, MD, Prof Eivind Berge, MD, Prof Gregory del Zoppo, MD, Prof Peter Sandercock, DM, Prof Richard L Lindley, MD, Geoff Cohen, PhD The Lancet Volume 379, Issue 9834, Pages 2364-2372 (June 2012) DOI: 10.1016/S0140-6736(12)60738-7 Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 1 Effects of rt-PA on early outcomes (7 days) Data are numbers, unless otherwise indicated. Degrees of freedom is 1. Treatment was administered up to 6 h after the stroke. rt-PA=recombinant tissue plasminogen activator. IST-3=Third International Stroke Trial. The Lancet 2012 379, 2364-2372DOI: (10.1016/S0140-6736(12)60738-7) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 2 Effects of rt-PA on outcomes at final follow-up Data are numbers, unless otherwise indicated. Treatment was administered up to 6 h after the stroke. rt-PA=recombinant tissue plasminogen activator. IST-3=Third International Stroke Trial. mRS=modified Rankin Scale. The Lancet 2012 379, 2364-2372DOI: (10.1016/S0140-6736(12)60738-7) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 3 Effects of rt-PA on alive and independent (mRS 0–2) and death by the end of follow-up and on symptomatic intracranial haemorrhage within the first 7 days, by time to treatment Data are numbers, unless otherwise indicated. rt-PA=recombinant tissue plasminogen activator. IST-3=Third International Stroke Trial. mRS=modified Rankin Scale. The Lancet 2012 379, 2364-2372DOI: (10.1016/S0140-6736(12)60738-7) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 4 Effect of rt-PA on alive and independent at the end of follow-up, subgrouped by age and time to treatment Data are numbers, unless otherwise indicated. rt-PA=recombinant tissue plasminogen activator. IST-3=Third International Stroke Trial. The Lancet 2012 379, 2364-2372DOI: (10.1016/S0140-6736(12)60738-7) Copyright © 2012 Elsevier Ltd Terms and Conditions