Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and sin-1 Stephen C. Clark, FRCSa, Catherine.

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Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and sin-1 Stephen C. Clark, FRCSa, Catherine Sudarshan, FRCSa, Jonathan Roughan, PhDb, Paul A. Flecknell, MRCVSb, John H. Dark, FRCSa The Journal of Thoracic and Cardiovascular Surgery Volume 117, Issue 3, Pages 556-564 (March 1999) DOI: 10.1016/S0022-5223(99)70335-1 Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 1 Neutrophil sequestration after administration of pentoxifylline, SIN-1, and InSP6. Results are shown as the mean value for animals in each intervention group (n = 5; group A, control; group B, inositol polyanions; group C, SIN-1; group D, pentoxifylline). Error bars indicate the 95% confidence interval. Pre-reperfusion value is shown at time 0. Note the significant attenuation of neutrophil sequestration in the intervention groups compared with controls. Mean absolute value at time 0 = 6.4 × 109/L. The Journal of Thoracic and Cardiovascular Surgery 1999 117, 556-564DOI: (10.1016/S0022-5223(99)70335-1) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 2 Platelet sequestration after administration of pentoxifylline, SIN-1, and InSP6. Results are shown as the mean value for animals in each intervention group (n = 5; group A, control; group B, inositol polyanions; group C, SIN-1; group D, pentoxifylline). Error bars indicate the 95% confidence interval. Pre-reperfusion value is shown at time 0. The interventions studied had no effect on platelet sequestration. Mean absolute value at time 0 = 265 × 109/L. The Journal of Thoracic and Cardiovascular Surgery 1999 117, 556-564DOI: (10.1016/S0022-5223(99)70335-1) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 3 Malonaldehyde levels after reperfusion with pharmacologic interventions. Results are shown as the mean value for animals in each intervention group (n = 5; group A, control; group B, inositol polyanions; group C, SIN-1; group D, pentoxifylline). Error bars indicate the 95% confidence interval. Pre-reperfusion value is shown at time 0. Note that malonaldehyde levels are significantly attenuated by pentoxifylline and InSP6. SIN-1 administration significantly elevated free radical levels compared with controls. The Journal of Thoracic and Cardiovascular Surgery 1999 117, 556-564DOI: (10.1016/S0022-5223(99)70335-1) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 4 Pulmonary venous Po2 (millimeters of mercury) with time after administration of pharmacologic interventions. Results are shown as the mean value for animals in each intervention group (n = 5; group A, control; group B, inositol polyanions; group C, SIN-1; group D, pentoxifylline). Error bars indicate the 95% confidence interval. Note superior function obtained with pentoxifylline treated lungs. The Journal of Thoracic and Cardiovascular Surgery 1999 117, 556-564DOI: (10.1016/S0022-5223(99)70335-1) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 5 Pulmonary vascular resistance after reperfusion with pharmacologic interventions. Results are shown as the mean value for animals in each intervention group (n = 5; group A, control; group B, inositol polyanions; group C, SIN-1; group D, pentoxifylline). Error bars indicate the 95% confidence interval. All interventions significantly reduced the pulmonary vascular resistance compared with controls. The Journal of Thoracic and Cardiovascular Surgery 1999 117, 556-564DOI: (10.1016/S0022-5223(99)70335-1) Copyright © 1999 Mosby, Inc. Terms and Conditions