In vivo tau imaging: Obstacles and progress

Slides:

Advertisements

Similar presentations

2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.

Advertisements

Sleep disruption changes across the disease trajectory: Pilot findings from the healthy patterns sleep study Nancy A. Hodgson, Albert J. Safi Alzheimer's.

DIAGNOSTIC ACCURACY AND CONFIDENCE IN THE CLINICAL DETECTION OF COGNITIVE IMPAIRMENT IN EARLY-STAGE PARKINSON’S DISEASE Kathryn A. Wyman-Chick, Phillip.

Relationship between Microstructural Degeneration of the Corpus Callosum, White Matter Hyperintensities, and Motor Function in Cognitively Intact Elderly

A SYSTEMATIC REVIEW AND META-ANALYSIS COMPARING QUALITY-OF-LIFE RATINGS FROM FAMILY AND PAID CAREGIVERS OF PEOPLE WITH DEMENTIA RESIDING IN CARE HOMES

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Forensic Science International

Localization of Hippocampal atrophy in Alzheimer's disease

Active Caspase-6 and Caspase-6-Cleaved Tau in Neuropil Threads, Neuritic Plaques, and Neurofibrillary Tangles of Alzheimer's Disease Huishan Guo, Steffen.

A NOVEL NEUROIMAGING APPROACH TO CAPTURE COGNITIVE RESERVE

Christine Bredfeldt, Kristen Rice, Lisa Alecxih

Comparison of tract-based spatial statistics and ROI-based approach in analyzing the white matter integrity in the elderly Huali Wang, Daniel Chang,

Application of Resource Utilization in Dementia (RUD) instrument in a global setting Anders Wimo, Anders Gustavsson, Linus Jönsson, Bengt Winblad, Ming-Ann.

Cerebral amyloid angiopathy, neurodegeneration, and dementia in a population-based study on the very elderly Finns (Vantaa 85+) Maarit Tanskanen, Mira.

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Japanese brain bank network for neuroscience research

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

The clinical, neuroanatomical, and neuropathologic phenotype of TBK1-associated frontotemporal dementia: A longitudinal case report Carolin A.M. Koriath,

Chronic Traumatic Encephalopathy

Volume 355, Issue 9202, (February 2000)

Intracranial Tumor Cell Migration and the Development of Multiple Brain Metastases in Malignant Melanoma Trude G. Simonsen, Jon-Vidar Gaustad, Einar.

Michael Ewers, Reisa A. Sperling, William E. Klunk, Michael W

RecA Current Biology Volume 17, Issue 11, Pages R395-R397 (June 2007)

Volume 58, Issue 4, Pages (October 2000)

Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Volume 59, Issue 2, Pages (February 2001)

Figure 1 Tau PET images in patients with Alzheimer disease

Biomarker Modeling of Alzheimer’s Disease

Figure 1 3D heat maps generated by GBM

Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study Kumar B. Rajan, Jennifer Weuve,

Volume 74, Issue 10, Pages (November 2008)

Confessions of a journal junkie

Fiber-Dependent and -Independent Toxicity of Islet Amyloid Polypeptide

Application of Resource Utilization in Dementia (RUD) instrument in a global setting Anders Wimo, Anders Gustavsson, Linus Jönsson, Bengt Winblad, Ming-Ann.

A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis Caitlin S. Latimer, Carol A. Shively,

Clifford R. Jack, Heather J. Wiste, Stephen D. Weigand, Terry M

Low-technology approaches

Prevalence and incidence of clinically diagnosed Alzheimer's disease dementia from 1994 to 2012 in a population study Kumar B. Rajan, Jennifer Weuve,

Magnesium sulphate as a technique of hypotensive anaesthesia

Volume 9, Issue 6, Pages (June 2009)

Archives of Physical Medicine and Rehabilitation

K. -C. Wang, E. Kwan, K. Aris, T. T. Egelhoff, A. I. Caplan, J. F

Nonhemophiliac musculoskeletal pseudotumor

Volume 18, Issue 3, Pages (March 2010)

[18F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: Specific detection of advanced phases of amyloid-β.

Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease Antoine Leuzy, Elena Rodriguez-Vieitez,

Deconstructing language disintegration: Primary progressive aphasias have specific tractographic signatures Colin Mahoney, Ian Malone, Ged Ridgway, Aisling.

News & Notes Journal of Allergy and Clinical Immunology

LIFESPAN OF ONE FOCUSED ULTRASOUND MEDIATED BLOOD-BRAIN BARRIER TREATMENT IN A MOUSE MODEL OF ALZHEIMER'S DISEASE Charissa Poon, Kullervo Hynynen Alzheimer's.

The influence of biological and technical factors on quantitative analysis of amyloid PET: Points to consider and recommendations for controlling variability.

Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective Matthew Baumgart, Heather M. Snyder,

Introduction: Evolution of military and veterans brain health research

Acute coronary syndromes: biology

Daniel Bos, Meike W. Vernooij, Renée F. A. G. de Bruijn, Peter J

Linus Jönsson, Pei-Jung Lin, Ara S. Khachaturian

Added value of 11C-PiB-PET imaging in the diagnosis of Alzheimer's disease Kristian Frederiksen, Anne-Mette Hejl, Ian Law, Steen Hasselbalch, Gunhild.

Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease W. Robert Bell, Yang An,

MR-less cortical surface-projection of PET images from 11C- and 18F-labeled radiotracers Vincent Doré, Pierrick Bourgeat, Luping Zhou, Jurgen Fripp,

Cerebral hypoperfusion is not associated with an increase in amyloid β pathology in middle-aged or elderly people Oskar Hansson, Sebastian Palmqvist,

Archives of Physical Medicine and Rehabilitation

Alzheimer's Association towards Guidelines for Dementia Care Practice: Recommendations with emphasis on high-quality, person-centered care in long-term.

Cognitive changes and dementia risk after traumatic brain injury: Implications for aging military personnel Andrea S. Vincent, Tresa M. Roebuck-Spencer,

K. -C. Wang, E. Kwan, K. Aris, T. T. Egelhoff, A. I. Caplan, J. F

A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis Caitlin S. Latimer, Carol A. Shively,

Nanotechnology in Thoracic Surgery

Michael Navitsky, Abhinay D. Joshi, Michael D. Devous, Michael J

Figure 1 NMF in ADD patients and classification of prodromal Alzheimer’s disease participants. Grey matter ... Figure 1 NMF in ADD patients and classification.

IP193. Controlled Compression Treatment With a Constant Resting Pressure and High Peak Working Pressure Toby Lundh Journal of Vascular Surgery Volume.

Bistra Iordanova, Matthew C. Murphy, William E. Klunk, Alberto L

Figure 2 Aβ-PET scans obtained using different tracers

Presentation transcript:

In vivo tau imaging: Obstacles and progress Victor L. Villemagne, Nobuyuki Okamura Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 10, Issue 3, Pages S254-S264 (June 2014) DOI: 10.1016/j.jalz.2014.04.013 Copyright © 2014 The Alzheimer's Association Terms and Conditions

Fig. 1 Chemical structure of currently available tau radiotracers. Most of them have been evaluated in clinical studies. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2014 10, S254-S264DOI: (10.1016/j.jalz.2014.04.013) Copyright © 2014 The Alzheimer's Association Terms and Conditions

Fig. 2 Autoradiographic studies of contiguous AD hemibrain sections with 18F-THK5105, 11C-PiB, and tau immunostaining, showing the different binding pattern of 18F-THK5105 and 11C-PiB, where 18F-THK5105 binding resembles tau immunostaining (modified from [110]). Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2014 10, S254-S264DOI: (10.1016/j.jalz.2014.04.013) Copyright © 2014 The Alzheimer's Association Terms and Conditions

Fig. 3 18F-T807 autoradiography on brain sections from different groups and its comparison with paired helical filament (PHF) tau and amyloid-β (Aβ) double immunohistochemistry (IHC). 18F-T807 colocalized with PHF tau but not with Aβ plaques. Low (top row) and high magnification from the framed areas (bottom row). Images of PHF tau (left) and Aβ (right) IHC double immunostaining and autoradiogram image (middle) from two adjacent sections (10 mm) from a PHF tau–rich brain (frontal lobe). Positive 18F-T807 labeling colocalized with immunostaining of PHF tau but not with Aβ plaques, as indicated by arrows. Fluorescent and autoradiographic images were obtained using a Fujifilm FLA-7000 imaging instrument (Fuji Photo Film Co., Ltd. Tokyo, Japan). Scale bars, 5 2 mm (Reproduced with permission from Alzheimer Dement [116]). Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2014 10, S254-S264DOI: (10.1016/j.jalz.2014.04.013) Copyright © 2014 The Alzheimer's Association Terms and Conditions