Volume 379, Issue 9813, Pages (January 2012)

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Volume 379, Issue 9813, Pages 322-334 (January 2012) Self-monitoring of oral anticoagulation: systematic review and meta-analysis of individual patient data Dr Carl Heneghan, DPhil, Alison Ward, PhD, Rafael Perera, DPhil, Clare Bankhead, DPhil, Alice Fuller, BSc, Richard Stevens, PhD, Kairen Bradford, MA, Sally Tyndel, PhD, Pablo Alonso-Coello, PhD, Prof Jack Ansell, MD, Rebecca Beyth, MD, Artur Bernardo, MD, Thomas Decker Christensen, DMSc, Manon Cromheecke, PhD, Robert G Edson, MA, Prof David Fitzmaurice, MD, Alain PA Gadisseur, PhD, Josep M Garcia-Alamino, RN, Chris Gardiner, PhD, Prof Michael Hasenkam, DMSc, Alan Jacobson, MD, Scott Kaatz, DO, Prof Farhad Kamali, PhD, Tayyaba Irfan Khan, PhD, Eve Knight, DipHPsych, Heinrich Körtke, PhD, Marcel Levi, PhD, Prof David Bruce Matchar, MD, Bárbara Menéndez-Jándula, MD, Ivo Rakovac, PhD, Christian Schaefer, Prof Andrea Siebenhofer, MD, Juan Carlos Souto, PhD, Prof Rubina Sunderji, PharmD, Prof Kenneth Gin, FRCPC, Prof Karen Shalansky, PharmD, Prof Heinz Völler, MD, Otto Wagner, MSc, Prof Armin Zittermann, PhD The Lancet Volume 379, Issue 9813, Pages 322-334 (January 2012) DOI: 10.1016/S0140-6736(11)61294-4 Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 1 Flow chart of studies The Lancet 2012 379, 322-334DOI: (10.1016/S0140-6736(11)61294-4) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 2 Hazard ratios for major outcomes Hazard ratios for thrombotic events (152 events in the control group, 114 in the self-monitoring group; A), haemorrhagic events (244 in the control group, 230 in the self-monitoring group; B), and death (274 in the control group, 247 in the self-monitoring group; C). The Lancet 2012 379, 322-334DOI: (10.1016/S0140-6736(11)61294-4) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 3 Major outcomes by sex, age, indication, type of monitoring and control group care Thrombosis (A), major haemorrhage (B), and death (C). O–E=observed minus expected. The Lancet 2012 379, 322-334DOI: (10.1016/S0140-6736(11)61294-4) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 4 Comparison by type of monitoring (self-monitoring compared with self-testing only) Thrombosis (A), major haemorrhage (B), and death (C). The Lancet 2012 379, 322-334DOI: (10.1016/S0140-6736(11)61294-4) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 5 Major outcomes in mechanical valve and atrial fibrillation by age and sex Patients with mechanical valve by sex and age (<65 years and ≥65 years; A) and patients with atrial fibrillation by sex and age (<65 years and ≥65 years; B). O–E=observed minus expected. The Lancet 2012 379, 322-334DOI: (10.1016/S0140-6736(11)61294-4) Copyright © 2012 Elsevier Ltd Terms and Conditions