Volume 20, Issue 7, Pages (July 2013)

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Volume 20, Issue 7, Pages 903-911 (July 2013) A Chemical Biology Approach to Interrogate Quorum-Sensing Regulated Behaviors at the Molecular and Cellular Level Colin A. Lowery, Susana Matamouros, Sherry Niessen, Jie Zhu, Jonathan Scolnick, Jenny M. Lively, Benjamin F. Cravatt, Samuel I. Miller, Gunnar F. Kaufmann, Kim D. Janda Chemistry & Biology Volume 20, Issue 7, Pages 903-911 (July 2013) DOI: 10.1016/j.chembiol.2013.05.009 Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 1 Structures of QS Signals (Left) AI-2 signals. (Right) Propyl-DPD, a QS antagonist against S. typhimurium. Chemistry & Biology 2013 20, 903-911DOI: (10.1016/j.chembiol.2013.05.009) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 2 Comparison of Proteins Identified across Three Biologic Replicates Chemistry & Biology 2013 20, 903-911DOI: (10.1016/j.chembiol.2013.05.009) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 3 Breakdown of Proteins Affected by a QS Antagonist, Propyl-DPD Protein classifications were determined using the PATRIC database (Gillespie et al., 2011). See also Tables S3 and S4 for a complete list of proteins affected by a factor of two with p ≤ 0.05. Chemistry & Biology 2013 20, 903-911DOI: (10.1016/j.chembiol.2013.05.009) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 4 Inhibition of Salmonella Invasion and Secretion by Propyl-DPD (A) Inhibition of S. typhimurium invasion of epithelial cells upon treatment with 25 μM propyl-DPD. Data represent five independent experiments, each performed in triplicate, and error bars represent SD. (B) Secretion profile of S. typhimurium upon treatment with 25 μM propyl-DPD. (C) Western blot analysis to monitor the effect of 25 μM propyl-DPD on SipC secretion. Chemistry & Biology 2013 20, 903-911DOI: (10.1016/j.chembiol.2013.05.009) Copyright © 2013 Elsevier Ltd Terms and Conditions