Familial Juvenile Hyperuricemic Nephropathy: Localization of the Gene on Chromosome 16p11.2—and Evidence for Genetic Heterogeneity Blanka Stibůrková,

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Familial Juvenile Hyperuricemic Nephropathy: Localization of the Gene on Chromosome 16p11.2—and Evidence for Genetic Heterogeneity Blanka Stibůrková, Jacek Majewski, Ivan Šebesta, Wenyong Zhang, Jurg Ott, Stanislav Kmoch The American Journal of Human Genetics Volume 66, Issue 6, Pages 1989-1994 (June 2000) DOI: 10.1086/302936 Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 1 Pedigrees of families with FJHN phenotypes used in this study. Haplotypes for markers on chromosome 16 are shown. The haplotype segregating with the disease locus in families A and B is indicated by a black bar. No haplotype consistent with linkage was found in family C. The American Journal of Human Genetics 2000 66, 1989-1994DOI: (10.1086/302936) Copyright © 2000 The American Society of Human Genetics Terms and Conditions

Figure 2 Four-point overlapping HLOD-score analysis of the four most informative markers in the linked region on chromosome 16. The arrow indicates the 1-LOD-unit confidence interval. The American Journal of Human Genetics 2000 66, 1989-1994DOI: (10.1086/302936) Copyright © 2000 The American Society of Human Genetics Terms and Conditions