Brent E. Palmer, PhD, Douglas G. Mack, PhD, Allison K

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Presentation transcript:

CD57 expression correlates with alveolitis severity in subjects with beryllium-induced disease Brent E. Palmer, PhD, Douglas G. Mack, PhD, Allison K. Martin, MS, Lisa A. Maier, MD, Andrew P. Fontenot, MD Journal of Allergy and Clinical Immunology Volume 120, Issue 1, Pages 184-191 (July 2007) DOI: 10.1016/j.jaci.2007.03.009 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 The distribution and frequency of beryllium-specific CD4+ T cells in blood and BAL from subjects with CBD. A, Representative example of intracellular cytokine staining on blood and BAL cells stimulated with medium, BeSO4 or SEB. B, The frequency of beryllium-specific (left) and SEB-reactive (right) CD4+ T cells from peripheral blood and BAL is shown. Solid lines represent the median values for each group. C, The proportion (mean ± SEM) of beryllium-specific (left) and SEB-reactive (right) CD4+ T cells within the different TH1-type cytokine-secreting T-cell populations from blood and BAL is depicted. Journal of Allergy and Clinical Immunology 2007 120, 184-191DOI: (10.1016/j.jaci.2007.03.009) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Expression of CD57 on blood and BAL CD4+ T cells. A, Representative example of CD57 staining on CD4+ T cells from blood and BAL of a patient with CBD is shown. B, The percentage of CD4+CD57+ T cells in blood of BeS, CBD, and normal control subjects and BAL of BeS, CBD, and sarcoidosis subjects is shown. Median values are indicated with solid lines. C, Correlation between the percentage of CD4+CD57+ T cells in the BAL and total BAL lymphocyte count. Journal of Allergy and Clinical Immunology 2007 120, 184-191DOI: (10.1016/j.jaci.2007.03.009) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Distribution of CD57 on memory T-cell populations in blood and BAL. A, Representative example of CD57 staining on CD4+ TCM, TEM, and TEMTD cells from blood is shown. B, The percentage of TCM, TEM, and TEMTD CD4+ T cells expressing CD57 on blood and BAL cells from patients with CBD (n = 12) is shown. Journal of Allergy and Clinical Immunology 2007 120, 184-191DOI: (10.1016/j.jaci.2007.03.009) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Distribution of CD57 on beryllium-specific, TH1-type cytokine-producing CD4+ T cells from subjects with CBD. Representative examples of CD57 expression on beryllium-specific, TH1-type cytokine-producing CD4+ T cells in blood (A) and BAL (B) are shown. The overall percentage of beryllium-specific (C) and SEB-reactive (D) TH1-type cytokine-secreting CD4+ T cells that express CD57 in blood and BAL is depicted. Solid lines represent the median values for each group. ND, Not detected. Journal of Allergy and Clinical Immunology 2007 120, 184-191DOI: (10.1016/j.jaci.2007.03.009) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Beryllium-specific CD4+CD57+ T cells from subjects with CBD exhibit reduced proliferative capacity. A, Representative density plots of CFSE-labeled PBMCs after 5 days of stimulation with medium (left), BeSO4 (middle), or αCD3 (right) are shown. B, The percentage of CD57+ and CD57− CFSElow CD4+ T cells from BeSO4-stimulated blood (left) and BAL (middle) and anti-CD3–stimulated blood (right) is shown. Median values are represented by solid lines. Journal of Allergy and Clinical Immunology 2007 120, 184-191DOI: (10.1016/j.jaci.2007.03.009) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions