Clinical courses of patients. Clinical courses of patients. Group A: RECIST PD and clinical PD occurred simultaneously; group B: RECIST PD without clinical PD and discontinued EGFR-TKI; group C: RECIST PD without clinical PD and continued EGFR-TKI; group D: no RECIST or clinical PD but discontinued EGFR-TKI; group E: no RECIST or clinical PD and continuing EGFR-TKI. EGFR, epidermal growth factor receptor; NSCLC, non-small-cell lung carcinoma; PD, progressive disease; RECIST, Response Evaluation Criteria in Solid Tumors; TKI, tyrosine kinase inhibitor. Yasushi Goto et al. ESMO Open 2017;2:e000214 Copyright © European Society for Medical Oncology. All rights reserved.