Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery Jane W. Newburger, MD, MPH, Richard A.

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Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery Jane W. Newburger, MD, MPH, Richard A. Jonas, MD, Janet Soul, MD, Barry D. Kussman, MBBCh, David C. Bellinger, PhD, MSc, Peter C. Laussen, MD, Richard Robertson, MD, John E. Mayer, MD, Pedro J. del Nido, MD, Emile A. Bacha, MD, Joseph M. Forbess, MD, Frank Pigula, MD, Stephen J. Roth, MD, MPH, Karen J. Visconti, PhD, Adre J. du Plessis, MBChB, MPH, David M. Farrell, MA, CCP, Ellen McGrath, RN, Leonard A. Rappaport, MD, David Wypij, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 135, Issue 2, Pages 347-354.e4 (February 2008) DOI: 10.1016/j.jtcvs.2007.01.051 Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 Plot of serial measurements of hematocrit according to perfusion phases, defined as follows: 1 = after induction of anesthesia; 2 = heparin given; 3 = 10 minutes after onset of cooling; 4 = onset of low-flow bypass; 5 = 10 minutes after onset of rewarming; 6 = start of warm flow; 7 = 60 minutes off bypass. Values are depicted as the mean ± 1 standard deviation. After adjustment for diagnostic group, statistically significant differences were found for phases 3, 4, 5, and 6. The Journal of Thoracic and Cardiovascular Surgery 2008 135, 347-354.e4DOI: (10.1016/j.jtcvs.2007.01.051) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure E2 Box plots of serum lactate levels measured 60 minutes after cessation of cardiopulmonary bypass according to hematocrit group. The solid bar within the box represents the median value, the upper boundary of the box the 75th percentile, and the lower boundary of the box the 25th percentile. The vertical lines extend to the 10th and 90th percentiles, with more extreme observations plotted as circles. The linear regression P value shown is for the effect of hematocrit group on lactate level, with adjustment for diagnostic group. The Journal of Thoracic and Cardiovascular Surgery 2008 135, 347-354.e4DOI: (10.1016/j.jtcvs.2007.01.051) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure E3 Box plots of Psychomotor Development Index and Mental Development Index scores at 1 year, according to hematocrit group. The solid bar within the box represents the median value, the upper boundary of the box the 75th percentile, and the lower boundary of the box the 25th percentile. The vertical lines extend to the 10th and 90th percentiles, with more extreme observations plotted as circles. The linear regression P values shown are for the effect of hematocrit group on outcome, with adjustment for diagnostic group. The Journal of Thoracic and Cardiovascular Surgery 2008 135, 347-354.e4DOI: (10.1016/j.jtcvs.2007.01.051) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure E4 Scatterplot of Psychomotor Development Index scores at 1 year as a function of hematocrit at the onset of low-flow bypass. The solid line was derived by linear regression of the data, and the dashed lines delimit the 95% confidence interval. The linear regression P value shown is for the effect of hematocrit at the onset of low-flow bypass on outcome, with adjustment for diagnostic group. Hct, Hematocrit. The Journal of Thoracic and Cardiovascular Surgery 2008 135, 347-354.e4DOI: (10.1016/j.jtcvs.2007.01.051) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions