Drugging Chromatin in Cancer: Recent Advances and Novel Approaches

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Presentation transcript:

Drugging Chromatin in Cancer: Recent Advances and Novel Approaches Sheng F. Cai, Chun-Wei Chen, Scott A. Armstrong Molecular Cell Volume 60, Issue 4, Pages 561-570 (November 2015) DOI: 10.1016/j.molcel.2015.10.042 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Strategies for Targeting Epigenetic Regulators (A) Inhibiting enzymatic activity with competitive small molecule compounds, (B) disrupting protein-protein interactions, and (C) using phthalimide-conjugated small molecules to redirect difficult-to-target proteins for proteasomal degradation via the cereblon (CRBN) E3 ubiquitin (Ub) ligase complex. Molecular Cell 2015 60, 561-570DOI: (10.1016/j.molcel.2015.10.042) Copyright © 2015 Elsevier Inc. Terms and Conditions