Increased dormancy of LKS CD150+ cells associated with steady-state aging. Increased dormancy of LKS CD150+ cells associated with steady-state aging. (A)

Slides:

Advertisements

Similar presentations

The Impact of Aging on CD4 T Cell Function 1.Define the impact of the defects in aged naïve CD4 T cells in memory development? 2.When in CD4 T cell development.

Advertisements

Critical Roles of Lysosomal Acid Lipase in Myelopoiesis

Volume 17, Issue 1, Pages (July 2015)

Stromal-Derived Factor-1α and Interleukin-7 Treatment Improves Homeostatic Proliferation of Naïve CD4+ T Cells after Allogeneic Stem Cell Transplantation

Attema et al., Supplementary Figure 1

Identification of Stem Cell Transcriptional Programs Normally Expressed in Embryonic and Neural Stem Cells in Alloreactive CD8+ T Cells Mediating Graft-versus-Host.

Homing efficiency, cell cycle kinetics, and survival of quiescent and cycling human CD34+ cells transplanted into conditioned NOD/SCID recipients by Anna.

Yumi Matsuzaki, Kentaro Kinjo, Richard C Mulligan, Hideyuki Okano

Distinct but phenotypically heterogeneous human cell populations produce rapid recovery of platelets and neutrophils after transplantation by Alice M.

The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease by Shan He, Fang.

Simple conditioning with monospecific CD4+CD25+ regulatory T cells for bone marrow engraftment and tolerance to multiple gene products by David-Alexandre.

MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.

Depletion of CD169+ cells leads to increased expression of CD25 on enterotoxin A–specific Vβ3+ T cells. Depletion of CD169+ cells leads to increased expression.

TLR5 signaling in murine bone marrow induces hematopoietic progenitor cell proliferation and aids survival from radiation by Benyue Zhang, Damilola Oyewole-Said,

MP cells are generated from naïve cells in the periphery.

Fig. 1 Increasing UCB cell dose impairs short-term progenitor cell engraftment. Increasing UCB cell dose impairs short-term progenitor cell engraftment.

A graphing calculator is required for some problems or parts of problems 2000.

by Anil Dangi, Lei Zhang, Xiaomin Zhang, and Xunrong Luo

by Ute Koch, Anne Wilson, Monica Cobas, Rolf Kemler, H

Role of monocytes in NK cell activity.

Fig. 5 A competent Fc is required for the antitumor immune response.

Human Treg cells express PlexinB1.

An Essential Role for IFN-γ in Regulation of Alloreactive CD8 T Cells Following Allogeneic Hematopoietic Cell Transplantation Wannee Asavaroengchai,

Enrichment of IL-12–Producing Plasmacytoid Dendritic Cells in Donor Bone Marrow Grafts Enhances Graft-versus-Leukemia Activity in Allogeneic Hematopoietic.

Highly Efficient Selection of CD4 and CD8 Lineage Thymocytes Supports an Instructive Model of Lineage Commitment Andrea Itano, Ellen Robey Immunity

FGF-2 signaling mediates expansion of HSPCs

STAT3 regulates IgE class switching in a Th2-type response.

SHIP is required for a functional hematopoietic stem cell niche

Volume 12, Issue 4, Pages (April 2013)

Volume 15, Issue 3, Pages (April 2016)

Normal priming and expansion of functional T cells in the spleen during concurrent co‐infection Normal priming and expansion of functional T cells in the.

STING stimulation in T cells inhibits cell cycle progression.

Volume 5, Issue 5, Pages (November 2015)

Volume 4, Issue 2, Pages (February 2009)

Volume 17, Issue 4, Pages (October 2002)

Volume 1, Issue 6, Pages (December 2007)

Impact of DNMT3A variants on proliferation and differentiation of HSPCs. Impact of DNMT3A variants on proliferation and differentiation of HSPCs. (A) Histograms.

Volume 5, Issue 5, Pages (November 2015)

Volume 1, Issue 6, Pages (December 2007)

ISS forming highly aggregated structures have decreased capability to induce maturation of human PDCs. Purified PDCs (105 cells) were stimulated with ISS.

CpG-C ISS lose their ability to induce IFN-α from human PDCs while retaining the ability to induce maturation when encapsulated into pH 5.75 liposomes.

MP cells consist of rapidly proliferating CD5hi and relatively quiescent CD5lo cells, both of which require CD28 signaling for Ki67 expression. MP cells.

Ag 85A–specific immune responses.

cMΦ develop into 4 subpopulations after birth.

Therapy model: CD34+CD33Del cells resist CD33-targeted immunotherapy.

Deletion of CD33 does not impair engraftment, hematopoietic repopulation, and function in NSGS mice. Deletion of CD33 does not impair engraftment, hematopoietic.

Neutrophil recruitment to the colonic lamina propria depends on CD4+ T cells. Neutrophil recruitment to the colonic lamina propria depends on CD4+ T cells.

Setdb1 has cell-intrinsic functions in B cell development.

MP cells are generated from naïve cells in the periphery.

Comparison of conventional NSG and hIL-7 expressing NSG humanized mice

MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.

CD8α+, CD8α−, and MoDCs from NOD.hCD205 mice express hCD205.

Differential induction of maturation by the different forms of CpG correlates with their ability to promote T cell activation. Differential induction of.

Induction of MHC-mismatched mixed chimerism depletes mature but not immature BM B cells by 60 days after HCT. Control and mixed chimeric NOD mice were.

Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice. Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice.

Loss of Tfh and GC B cells in 2KO-Bcl6TC mice.

BMS blocks functional responses in primary immune cells driven by IFNα

Volume 23, Issue 4, Pages (October 2005)

Conversion of CD11bhighCD27high NK cells into MDSCs leads to CD11bhighCD27high and CD11bhighCD27low NK cell reduction. Conversion of CD11bhighCD27high.

CD49b+ cells from tumor-bearing mice are more prone to conversion into MDSCs compared with naive CD49b+ cells. CD49b+ cells from tumor-bearing mice are.

CD11bhighCD27high conventional NK cells are converted into MDSCs

by Samuel J. Taylor, Johanna M. Duyvestyn, Samantha A. Dagger, Emma J

Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation by Kate A. Markey, Tatjana.

Circulating leukocytes do not efficiently infiltrate advanced solid tumors in IL-15/IL-15Rα complex–treated RIP1-Tag2 mice. Circulating leukocytes do not.

Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex treatment. Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex.

Anti-CD40 activates TAMs and recruits inflammatory monocytes.

Effect of HDC on the ROS production in mouse lungs after melanoma cell inoculation. Effect of HDC on the ROS production in mouse lungs after melanoma cell.

B-cell development in young Pax5+/− mice.

Meningeal γδ T cells are biased toward IL-17 production.

Fetal-derived γδ T cells infiltrate the meninges from birth.

Presentation transcript:

Increased dormancy of LKS CD150+ cells associated with steady-state aging. Increased dormancy of LKS CD150+ cells associated with steady-state aging. (A) Experimental scheme of transplantation. Young mice were transplanted with 7.5–10 × 104 CFSE-labeled LKS cells from young (8–12 wk old) or aged (64–72 wk old) mice and analyzed after 4 wk. (B) Representative dot plot analysis of lineage-depleted BM gated on donor Lin− cells. Dashed lines represent zero division. Number of donor LKS CD150+ cells having undergone indicated numbers of divisions were calculated. Graph shows mean ± SD (n = 3 mice from two to three independent experiments). Hitoshi Takizawa et al. J Exp Med 2011;208:273-284 © 2011 Takizawa et al.