HOXA-10 and E-cadherin expression in the endometrium of women with recurrent implantation failure and recurrent miscarriage Yihua Yang, Ph.D., Xiaoyan.

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Presentation transcript:

HOXA-10 and E-cadherin expression in the endometrium of women with recurrent implantation failure and recurrent miscarriage Yihua Yang, Ph.D., Xiaoyan Chen, M.Phil., Sotirios H. Saravelos, M.B.B.S., Yingyu Liu, M.Phil, Jin Huang, Ph.D., Jiamiao Zhang, M.Phil., Tin Chiu Li, M.D., Ph.D. Fertility and Sterility Volume 107, Issue 1, Pages 136-143.e2 (January 2017) DOI: 10.1016/j.fertnstert.2016.09.016 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Cellular localization of HOXA-10 and E-cadherin in endometrial cells. Immunofluorescence staining of (A) HOXA-10 and (D) E-cadherin were performed on normal endometrium. DAPI was used to stain the nuclei (B, E). Then the pictures were merged together (C, F). Magnification = ×400. Scale bar = 50 μm. Fertility and Sterility 2017 107, 136-143.e2DOI: (10.1016/j.fertnstert.2016.09.016) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Correlation of HOXA-10 and E-cadherin expression in endometrium of different groups of women. Representative images with various levels of HOXA-10 and E-cadherin staining in endometrium. Staining levels of (A, D) strong from a normal control (NC) subject, (B, E) moderate from a recurrent implantation failure (RIF) patient, and (C, F) weak from a recurrent miscarriage (RM) patient are shown. Magnification = ×400. Scalebar = 50 μm. Correlation of HOXA-10 and E-cadherin expression in different groups of women were compared by means of Student t test. The H-scores of HOXA-10 in (G) glandular epithelium and (H) stroma cells and of (I) E-cadherin are shown, the data plotted as mean ± SD. NS = not significant. *P<.05; **P<.01; ***P<.001. Fertility and Sterility 2017 107, 136-143.e2DOI: (10.1016/j.fertnstert.2016.09.016) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Positive correlation of HOXA-10 and E-cadherin expression. Representative images of (A, B) HOXA-10 and (D, E) E-cadherin expression in NC and RM patients in sequential sections. The H-scores of HOXA-10 in (C) glandular epithelium and (F) stroma cells were positively correlated with H-scores of E-cadherin respectively in all women examined. Magnification = ×400. Scale bar = 50 μm. Abbreviations as in Figure 2. Fertility and Sterility 2017 107, 136-143.e2DOI: (10.1016/j.fertnstert.2016.09.016) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Positive correlation of glandular and stroma cell HOXA-10 expression. Fertility and Sterility 2017 107, 136-143.e2DOI: (10.1016/j.fertnstert.2016.09.016) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions