Multiple Choice Test Tips EXAM Lectures 1 to 9 are covered (that includes today) Wednesday Help Session (optional) 90 minute test LILY 1105 Multiple Choice Test Tips Go through the test once and answer all the questions Move on if you get stuck Save some time at the end to double-check Change your answers if you wish; research shows that most students gain more than they lose on changes answers. This advice is very dependent on the person feel free to ignore!
Major Histocompatibility Complex Genetic region containing large number of different immune related genes Cell Surface molecules that were first associated with transplantation histocompatibility antigens transplantation antigens Histo = tissue Normal genes that do not rearrange (somatic recombination) MHC genes are expressed co-dominantly (both copies are expressed)
Major Histocompatibility Complex In humans the MHC locus is called the HLA complex and is located on Chromosome 6 In mice the MHC locus is called the H-2 complex and is located on chromosome 17 Each locus is further subdivided into 3 regions: Class I MHC region - Present antigen to CD8+ Cytotoxic T-cells Class II MHC region - Present antigen to CD4+ Helper T-cells (professional APCs) Class III MHC region - Usually secreted proteins such as complement and cytokines