Effects of heparin, desmopressin, and isovolemic hemodilution with dextran on thrombus formation in synthetic vessel grafts inserted into the vena cava.

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Presentation transcript:

Effects of heparin, desmopressin, and isovolemic hemodilution with dextran on thrombus formation in synthetic vessel grafts inserted into the vena cava of the rabbit Lieselotte Frost-Arner, MD, PhD, David Bergqvist, MD, PhD Journal of Vascular Surgery Volume 28, Issue 3, Pages 506-513 (September 1998) DOI: 10.1016/S0741-5214(98)70137-5 Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 1 Blood flow in vena cava in control group (C) and in animals that underwent hemodilution (H), heparin treatment only (Hep), hemodilution in combination with heparin (H+Hep), or hemodilution in combination with desmopressin (H+D). Groups that underwent hemodilution are indicated with hatched bars. Filled bars indicate groups that received hemodilution in combination with heparin and that were studied for 2 weeks. Flow values are given relative to initial value determined in each animal (n = 5-11; see Table I). A shows flow values immediately after hemodilution. In groups without hemodilution (open bars), the flow remained unchanged. In all groups with hemodilution, the increase in blood flow, as compared with initial flow in each group, was significant (Student's t-test, paired analysis). B shows flow after declamping. No significant differences were observed between groups (Bonferroni method). C shows flow values after 2 days and 2 weeks. Occluded vessels, when present, were included in the calculation of mean values. Statistical differences compared with control group are indicated (Bonferroni method). *P < .05; **P < .01; ***P < .001. Journal of Vascular Surgery 1998 28, 506-513DOI: (10.1016/S0741-5214(98)70137-5) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig 2 A shows thrombus mass in controls (C) and in animals that received hemodilution (H), heparin treatment only (Hep), hemodilution in combination with heparin (H+Hep), or hemodilution in combination with desmopressin acetate (H+D). Groups that underwent hemodilution are indicated with hatched bars. Filled bars indicate groups that underwent hemodilution in combination with heparin and that were studied for 2 weeks. The thrombus mass was significantly lower in all groups that underwent hemodilution as compared with the control group. Weight in the group that underwent hemodilution in combination with heparin was significantly less than in the group that underwent hemodilution (†). No statistically significant differences were observed between groups that underwent hemodilution and groups that underwent hemodilution in combination with desmopressin. Statistical comparisons were made with the Bonferroni method. In B, thrombus mass (from A) is plotted against flow (data from C in Fig 1; n = 5-11). Journal of Vascular Surgery 1998 28, 506-513DOI: (10.1016/S0741-5214(98)70137-5) Copyright © 1998 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions