Characteristics of advanced fibrosis in rheumatic diseases include marked lymphoid hyperplasia (A, 20×, H&E), peribronchiolar lymphoid hyperplasia with.

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Characteristics of advanced fibrosis in rheumatic diseases include marked lymphoid hyperplasia (A, 20×, H&E), peribronchiolar lymphoid hyperplasia with associated peribronchiolar metaplasia (B, 20×, H&E), presence of an non-specific interstitial pneumonia pattern of disease in the background which may be mistaken as ‘normal’ in comparison with the large zones of fibrosis (C, 20×, H&E), and follicular bronchiolitis (D, 400×, H&E). Characteristics of advanced fibrosis in rheumatic diseases include marked lymphoid hyperplasia (A, 20×, H&E), peribronchiolar lymphoid hyperplasia with associated peribronchiolar metaplasia (B, 20×, H&E), presence of an non-specific interstitial pneumonia pattern of disease in the background which may be mistaken as ‘normal’ in comparison with the large zones of fibrosis (C, 20×, H&E), and follicular bronchiolitis (D, 400×, H&E). Maxwell Smith et al. J Clin Pathol 2013;66:896-903 Copyright © by the BMJ Publishing Group Ltd & Association of Clinical Pathologists. All rights reserved.