Antimicrobial RNases of Human Skin Michael Zasloff  Journal of Investigative Dermatology  Volume 129, Issue 9, Pages 2091-2093 (September 2009) DOI: 10.1038/jid.2009.216 Copyright © 2009 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Liberating antimicrobial RNases in the stratum corneum. RNases (such as RNase 5 and RNase 7) and RNase inhibitor (RI) are synthesized within the proliferating layers of the epidermis. RI inactivates both the antimicrobial and the catalytic activities of these RNases through complex formation within the deeper epidermal layers. As the keratinocytes mature and create the stratum corneum, a protease (not absolutely identified) degrades the RNase inhibitor, releasing the RNases, which can now exert their antimicrobial activity within the stratum corneum. Journal of Investigative Dermatology 2009 129, 2091-2093DOI: (10.1038/jid.2009.216) Copyright © 2009 The Society for Investigative Dermatology, Inc Terms and Conditions