Osteoclast function, bone turnover and inflammatory cytokines during infective exacerbations of cystic fibrosis Elizabeth F. Shead, Charles S. Haworth,

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Presentation transcript:

Osteoclast function, bone turnover and inflammatory cytokines during infective exacerbations of cystic fibrosis Elizabeth F. Shead, Charles S. Haworth, Helen Barker, Diana Bilton, Juliet E. Compston Journal of Cystic Fibrosis Volume 9, Issue 2, Pages 93-98 (March 2010) DOI: 10.1016/j.jcf.2009.11.007 Copyright © 2009 European Cystic Fibrosis Society Terms and Conditions

Fig. 1 Variations in osteoclast formation and activity during an infective exacerbation. (A) Formation of TRAP positive cells and (B) resorption activity both increased at day 1 and day 14 compared to baseline (*p<0.05). Journal of Cystic Fibrosis 2010 9, 93-98DOI: (10.1016/j.jcf.2009.11.007) Copyright © 2009 European Cystic Fibrosis Society Terms and Conditions

Fig. 2 Variations in markers of bone metabolism during infective exacerbation. (A) Serum levels of osteocalcin at baseline were significantly lower than normal control levels. (B) Serum levels of NTx were significantly increased at day 14 compared to baseline (*p<0.05). Journal of Cystic Fibrosis 2010 9, 93-98DOI: (10.1016/j.jcf.2009.11.007) Copyright © 2009 European Cystic Fibrosis Society Terms and Conditions

Fig. 3 Correlations between osteoclast formation and activity and markers of bone metabolism during infective exacerbation. (A) Formation of TRAP positive cells and resorption activity (p<0.05) and (B) serum levels of NTx and resorption activity (p<0.01) were significantly correlated during infective exacerbation. Journal of Cystic Fibrosis 2010 9, 93-98DOI: (10.1016/j.jcf.2009.11.007) Copyright © 2009 European Cystic Fibrosis Society Terms and Conditions