The diagnostic accuracy of procalcitonin for bacteraemia: a systematic review and meta- analysis  S.H. Hoeboer, P.J. van der Geest, D. Nieboer, A.B.J. Groeneveld  Clinical Microbiology and Infection  Volume 21, Issue 5, Pages 474-481 (May 2015) DOI: 10.1016/j.cmi.2014.12.026 Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Summary receiver-operating characteristic (SROC) curve plot of procalcitonin for the diagnosis of bacteraemia, including all studies (n = 58). Individual studies are shown as open circles. Summary point is shown as a closed square, representing sensitivity estimates pooled by using bivariate random-effects regression model. The area under the SROC curve (dashed line) is 0.79, pooled sensitivity is 76% and specificity is 69%. The 95% confidence region displays the 95% confidence interval of the pooled sensitivity and specificity. The 95% prediction region is the region for a forecast of the true sensitivity and specificity in a future study. Clinical Microbiology and Infection 2015 21, 474-481DOI: (10.1016/j.cmi.2014.12.026) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Supplemental Fig. 2 Accuracy estimates analysis for bacteraemia versus non-bacteraemia. Including all studies (n = 49). Clinical Microbiology and Infection 2015 21, 474-481DOI: (10.1016/j.cmi.2014.12.026) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Supplemental Fig. 3 Evaluation of publication bias. The Deeks funnel plot asymmetry test was nonsignificant (p 0.13). Individual studies are shown as open circles and the interrupted line represents the regression line; ESS, effective sample size. Clinical Microbiology and Infection 2015 21, 474-481DOI: (10.1016/j.cmi.2014.12.026) Copyright © 2015 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions