Transcriptional and translational map of HBV

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Transcriptional and translational map of HBV Transcriptional and translational map of HBV. The figure shows the physical map of the HBV genome. Transcriptional and translational map of HBV. The figure shows the physical map of the HBV genome. The inner circle depicts the rcDNA with the reverse transcriptase attached to the 5′ end of the complete minus-strand DNA (solid sphere) and a capped RNA oligomer attached to the 5′ end of the incomplete plus-strand DNA (solid half sphere). The positions of the direct repeats, DR1 and DR2, as well as the positions of the two enhancers, EN1 and EN2, are indicated. The outer circle depicts the three major viral RNAs, the core (C) or pgRNA, the pre-S (L) mRNA, and the S mRNA. The common 3′ ends of the three mRNAs are indicated by the letters A. Not shown in the figure is the putative X mRNA that spans the X coding region and terminates at the site indicated for the other three mRNAs. The four protein-coding regions are shown between the inner and outer circles. They include the precore (PC) and core genes, the polymerase gene, and the X gene. The envelope genes pre-S1 (L), pre-S2 (M), and surface (S) overlap with the polymerase open reading frame. Christoph Seeger, and William S. Mason Microbiol. Mol. Biol. Rev. 2000; doi:10.1128/MMBR.64.1.51-68.2000