Hematopoietic Cell Transplantation as Curative Therapy for Idiopathic Myelofibrosis, Advanced Polycythemia Vera, and Essential Thrombocythemia Daniella.

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Presentation transcript:

Hematopoietic Cell Transplantation as Curative Therapy for Idiopathic Myelofibrosis, Advanced Polycythemia Vera, and Essential Thrombocythemia Daniella M.B. Kerbauy, Theodore A. Gooley, George E. Sale, Mary E.D. Flowers, Kristine C. Doney, George E. Georges, Joanne E. Greene, Michael Linenberger, Effie Petersdorf, Brenda M. Sandmaier, Bart L. Scott, Mohamed Sorror, Derek L. Stirewalt, F. Marc Stewart, Robert P. Witherspoon, Rainer Storb, Frederick R. Appelbaum, H. Joachim Deeg Biology of Blood and Marrow Transplantation Volume 13, Issue 3, Pages 355-365 (March 2007) DOI: 10.1016/j.bbmt.2006.11.004 Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Overall survival. (A) All patients in the study (n = 104) compared to patients given allogeneic transplants after myeloablative conditioning regimens (n = 92). (B) Survival among the 92 allogeneic recipients prepared with myeloablative regimens by type of regimen. Biology of Blood and Marrow Transplantation 2007 13, 355-365DOI: (10.1016/j.bbmt.2006.11.004) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Impact of disease parameters on survival (same patients as in Figure 1). (A) Effect of Dupriez risk category. (B) Effect of the degree of marrow fibrosis (not graded in 5 patients). Biology of Blood and Marrow Transplantation 2007 13, 355-365DOI: (10.1016/j.bbmt.2006.11.004) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Overall survival among patients without leukemic transformation conditioned with myeloablative regimens and transplanted from HLA-identical sibling donors (n = 47) or unrelated donors who were HLA-identical by high-resolution typing (n = 20). Biology of Blood and Marrow Transplantation 2007 13, 355-365DOI: (10.1016/j.bbmt.2006.11.004) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Impact of primary diagnosis on transplantation outcome (same patients as in Figure 1). Biology of Blood and Marrow Transplantation 2007 13, 355-365DOI: (10.1016/j.bbmt.2006.11.004) Copyright © 2007 American Society for Blood and Marrow Transplantation Terms and Conditions