Is increased joint loading detrimental to obese patients with knee osteoarthritis? A secondary data analysis from a randomized trial  M. Henriksen, D.J. Hunter, E.B. Dam, S.P. Messier, T.P. Andriacchi, L.S. Lohmander, J. Aaboe, M. Boesen, H. Gudbergsen, H. Bliddal, R. Christensen  Osteoarthritis and Cartilage  Volume 21, Issue 12, Pages 1865-1875 (December 2013) DOI: 10.1016/j.joca.2013.10.003 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Representative images from the 3D reconstructed 2 mm sagittal 3D FLASH gradient-echo (left), sagittal non fat sat DUAL turbo spin echo proton density weighted (middle) and T2-weighted (right) sequences in the medial part of the medial tibiofemoral joint. The FLASH image indicates reduced cartilage thickness (cartilage loss) in the anterior weight bearing region of the femur (between the vertical arrows) corresponding to a grade 2 cartilage loss (defined as any cartilage loss in 10–75% of region cartilage surface area). Because of the limited contrast between fluid and cartilage in the FLASH sequence image, the score was confirmed from the proton density weighted (middle) and T2-weighted (right) images indicating fluid between the femoral and tibial cartilage (horizontal arrows). Note the anterior osteophyte, bone marrow changes in the anterior tibia, and a moderate effusion in the medial recess and posterior to the meniscus. Osteoarthritis and Cartilage 2013 21, 1865-1875DOI: (10.1016/j.joca.2013.10.003) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Study profile illustrating the flow of patients through the study. Osteoarthritis and Cartilage 2013 21, 1865-1875DOI: (10.1016/j.joca.2013.10.003) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions