CKD in Aboriginal Australians

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Presentation transcript:

CKD in Aboriginal Australians Wendy E. Hoy, FRACP, Priscilla Kincaid-Smith, FRACP, Michael D. Hughson, MD, Agnes B. Fogo, MD, Rajalingam Sinniah, MD, John Dowling, MBBS, Terrence Samuel, MBBS, Susan A. Mott, MPH, Rebecca N. Douglas-Denton, BSc, John F. Bertram, PhD American Journal of Kidney Diseases Volume 56, Issue 5, Pages 983-993 (November 2010) DOI: 10.1053/j.ajkd.2010.05.010 Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Representation of Australian remoteness classifications. Australian Bureau of Statistics ARIA+ (Accessibility/Remoteness Index of Australia) measure of remoteness (2006). Source: Australian Bureau of Statistics.3 American Journal of Kidney Diseases 2010 56, 983-993DOI: (10.1053/j.ajkd.2010.05.010) Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Recent annual incidence of indigenous Australians starting renal replacement therapy by state/territory, person per million. Source: ANZDATA Registry 2009 Report.6 American Journal of Kidney Diseases 2010 56, 983-993DOI: (10.1053/j.ajkd.2010.05.010) Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Increase in prevalence of morbidities by age in one remote community in the Northern Territory. Abbreviation: CI, confidence interval. Reproduced from Hoy et al22 with permission of Elsevier. American Journal of Kidney Diseases 2010 56, 983-993DOI: (10.1053/j.ajkd.2010.05.010) Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Odds ratios (95% confidence intervals [CIs]) for selected conditions in adults in 3 remote Northern Territory communities relative to rates in the AusDiab (Australian Diabetes, Obesity and Lifestyle) study adjusted for age and sex. Reproduced from Hoy et al24 with permission of John Wiley & Sons. American Journal of Kidney Diseases 2010 56, 983-993DOI: (10.1053/j.ajkd.2010.05.010) Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions

Figure 5 Increase in urine albumin-creatinine ratio (ACR) with age. American Journal of Kidney Diseases 2010 56, 983-993DOI: (10.1053/j.ajkd.2010.05.010) Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions

Figure 6 Hazard ratios (HRs; confidence intervals [CIs]) for natural deaths in young adults (aged 15-37 years), those with birth weight less than their group median versus those of higher birth weight, adjusted for birth interval, age, and sex. Reproduced from Hoy and Nicol39 with permission of The Medical Journal of Australia. American Journal of Kidney Diseases 2010 56, 983-993DOI: (10.1053/j.ajkd.2010.05.010) Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions

Figure 7 Natural deaths by baseline albumin-creatinine ratio (ACR) during a 10-year follow-up. Source: Wang et al.31 American Journal of Kidney Diseases 2010 56, 983-993DOI: (10.1053/j.ajkd.2010.05.010) Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions

Figure 8 Distribution of mean glomerular volume (MGV) in renal biopsy specimens from Aboriginal people by category of remoteness and comparison with non-Aboriginal Australian biopsy specimens. American Journal of Kidney Diseases 2010 56, 983-993DOI: (10.1053/j.ajkd.2010.05.010) Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions

Figure 9 Distribution of glomerular number in right kidney at coronial autopsy, Aboriginal versus non-Aboriginal. American Journal of Kidney Diseases 2010 56, 983-993DOI: (10.1053/j.ajkd.2010.05.010) Copyright © 2010 National Kidney Foundation, Inc. Terms and Conditions