Michael Charlton, Bo Ahlman, K.Sreekumaran Nair Gastroenterology

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The effect of insulin on human small intestinal mucosal protein synthesis Michael Charlton, Bo Ahlman, K.Sreekumaran Nair Gastroenterology Volume 118, Issue 2, Pages 299-306 (February 2000) DOI: 10.1016/S0016-5085(00)70212-5 Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 1 Time course of glucose levels during insulin deprivation. Mean (±SEM) results are shown for each time point. Time (minutes) refers to the time before (−) or after (+) initiation of isotope infusion. Glucose levels initially increased during insulin deprivation and were stable during the period of isotope infusion (time 0 → +240 minutes). Gastroenterology 2000 118, 299-306DOI: (10.1016/S0016-5085(00)70212-5) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 2 Time courses of the enrichments of 13C-KIC and 13CO2 (atom percent excess). Enrichments were all stable during the periods used for kinetics calculations. Isotopic steady state was achieved by 60 minutes. Controls, healthy nondiabetic controls; type 1 DM (INS+), type 1 diabetes during insulin treatment; and type 1 DM (INS−), type 1 diabetes during insulin deprivation. Gastroenterology 2000 118, 299-306DOI: (10.1016/S0016-5085(00)70212-5) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 3 Individual values and means (joined by lines) for mucosal 13C-leucine enrichment at 240 minutes. Mucosal samples were obtained through endoscopic biopsy. Gastroenterology 2000 118, 299-306DOI: (10.1016/S0016-5085(00)70212-5) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 4 Small intestinal mucosal protein FSRs calculated using plasma 13C-KIC (▩) and mucosal tissue-free fluid (●) for estimation of precursor pool enrichment. The FSR of mucosal proteins was significantly lower in patients with type 1 diabetes during insulin deprivation (type 1, ins−) than in patients with type 1 diabetes during insulin treatment (type 1 DM, ins+) and healthy nondiabetic controls. *P ± 0.04 compared with patients with type 1 diabetes during insulin treatment and controls. Gastroenterology 2000 118, 299-306DOI: (10.1016/S0016-5085(00)70212-5) Copyright © 2000 American Gastroenterological Association Terms and Conditions