Murine ultrasound imaging for circumferential strain analyses in the angiotensin II abdominal aortic aneurysm model John T. Favreau, BS, Binh T. Nguyen,

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Murine ultrasound imaging for circumferential strain analyses in the angiotensin II abdominal aortic aneurysm model John T. Favreau, BS, Binh T. Nguyen, MD, Ian Gao, BS, Peng Yu, MD, Ming Tao, MD, Jacob Schneiderman, MD, Glenn R. Gaudette, PhD, C. Keith Ozaki, MD Journal of Vascular Surgery Volume 56, Issue 2, Pages 462-469 (August 2012) DOI: 10.1016/j.jvs.2012.01.056 Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 1 Segments of interest analyzed in the thoracic and abdominal aorta. Celiac trunk (CT), superior mesenteric artery (SMA), and renal arteries (RAs). The thoracic region = cross-section 5 mm proximal to the CT; the supraceliac region = cross-section 1 mm proximal to the CT; the paravisceral region = cross-section between the CT and SMA; and the juxtarenal region = cross-section 1 mm distal to the SMA. Journal of Vascular Surgery 2012 56, 462-469DOI: (10.1016/j.jvs.2012.01.056) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 2 Sample ultrasound scan image of an aorta, with the manually drawn spline shown (solid orange). Green traces show the path of the tracking points (yellow) throughout several cardiac cycles. The dashed red line indicates a region that has poor contrast (likely due to a branching vessel) and therefore poor tracking. These regions were dropped from the analyses to improve accuracy. Yellow scale bar = 1 mm. Journal of Vascular Surgery 2012 56, 462-469DOI: (10.1016/j.jvs.2012.01.056) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 3 Comparison of baseline preoperative strain magnitudes across six aortic locations between normal chow and high-fat diet mice. Statistical statements are noted in the inset table. No statistically significant differences were found between mice of different diets in any aortic location, although differentials were noted among segments as depicted. All statistical statements indicate that P < .05; all groups contain 15 or more animals. *Indicates statistical difference from high-fat ascending aorta; #indicates statistical difference from normal chow ascending aorta; and @indicates statistical difference from high-fat aortic arch. Journal of Vascular Surgery 2012 56, 462-469DOI: (10.1016/j.jvs.2012.01.056) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 4 A, Short-term effects of angiotensin II (Ang II) treatment on animals fed on normal chow diets. B, Short-term effects of Ang II treatment on animals consuming only high-fat diets since week 10 of age. C, Long-term effects of Ang II treatment on normal chow animals. D, Long-term effects of Ang II on high-fat animals. *Indicates P < .05. Journal of Vascular Surgery 2012 56, 462-469DOI: (10.1016/j.jvs.2012.01.056) Copyright © 2012 Society for Vascular Surgery Terms and Conditions

Fig 5 Effects of angiotensin II (Ang II) and aneurysmal degeneration on aortic wall strain. Data are reported as percent change in strain from preoperative strain. The Ang II group contains only animals that did not have aneurysms at day 3 from the early study. Day 14 and day 28 aneurysmal degeneration groups only contain data from animals that had aneurysmal expansion (increase in size of 150% or more) detected via ultrasound scans. Data for normal chow and high-fat groups are shown in (A) and (B), respectively. Journal of Vascular Surgery 2012 56, 462-469DOI: (10.1016/j.jvs.2012.01.056) Copyright © 2012 Society for Vascular Surgery Terms and Conditions