Inês Mendes Pinto, Boris Rubinstein, Rong Li Biophysical Journal

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Presentation transcript:

Force to Divide: Structural and Mechanical Requirements for Actomyosin Ring Contraction Inês Mendes Pinto, Boris Rubinstein, Rong Li Biophysical Journal Volume 105, Issue 3, Pages 547-554 (August 2013) DOI: 10.1016/j.bpj.2013.06.033 Copyright © 2013 Biophysical Society Terms and Conditions

Figure 1 Actin and myosin-II filament distribution along the cytokinetic ring. (A, upper panel) Illustration of a cell with an actomyosin filamentous ring (inside the dashed rectangle). (A, lower panel) Sliding of actin filaments by myosin-II motor produces contraction of actin filaments organized in a sarcomere-like organization. (B) Myosin-II motor operates in a contracting (top) and expanding (bottom) configuration with antiparallel actin filaments. Myosin-II motor sliding produces equal rates of contraction and expansion. (Arrowheads) Barbed end of the actin filaments. (b) Barbed and (p) pointed actin filament ends. Biophysical Journal 2013 105, 547-554DOI: (10.1016/j.bpj.2013.06.033) Copyright © 2013 Biophysical Society Terms and Conditions

Figure 2 Different myosin-II velocities promote contraction due to actin filament buckling. The left-most myosin-II pulls the upper filament to the left faster than the neighboring myosin, thus promoting an extensile stress. At the same time, the lower filament is pulled to the right by the leftmost myosin-II faster than by its neighboring motor, thus creating a compressive stress that leads to buckling (adapted from Figure 6 of Lenz et al. (36)). (b) Barbed and (p) pointed actin filament ends. Biophysical Journal 2013 105, 547-554DOI: (10.1016/j.bpj.2013.06.033) Copyright © 2013 Biophysical Society Terms and Conditions

Figure 3 (A) Force generation due to actin depolymerization coupled with crosslinking (adapted from Figure 5A of Mendes Pinto et al. (45)). (B) Myosin-II motor sliding coupled with actin depolymerization in a contracting (top) and expanding (bottom) actin filaments configuration of an antiparallel actin filament structure. The two mechanisms generate a rate imbalance in favor of contraction. (b) Barbed and (p) pointed actin filament ends. Biophysical Journal 2013 105, 547-554DOI: (10.1016/j.bpj.2013.06.033) Copyright © 2013 Biophysical Society Terms and Conditions