Spectrum and progression of disease from condyloma to aggressive anogenital squamous cell carcinoma in 3 HIV-positive patients Olaf Rodriguez, BS, Carrie.

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Spectrum and progression of disease from condyloma to aggressive anogenital squamous cell carcinoma in 3 HIV-positive patients Olaf Rodriguez, BS, Carrie L. Kovarik, MD JAAD Case Reports Volume 2, Issue 1, Pages 47-50 (January 2016) DOI: 10.1016/j.jdcr.2015.12.003 Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Biopsy of pedunculated perianal lesion from patient 1. The biopsy shows a pedunculated condyloma with a transition zone to SCCIS (Hematoxylin-eosin stain; original magnification: ×40.) JAAD Case Reports 2016 2, 47-50DOI: (10.1016/j.jdcr.2015.12.003) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 HPV-16 immunostaining of the lesion in Fig 1. Significant HPV-16 nuclear staining is observed within the pedunculated lesion excised from patient 1. HPV-16 staining can be seen within the SCCIS region of the specimen (arrow 1) and within the adjacent condyloma (arrow 2) (original magnification: ×40.) JAAD Case Reports 2016 2, 47-50DOI: (10.1016/j.jdcr.2015.12.003) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 HPV-related oral leukoplakia with biopsy-proven invasive squamous cell carcinoma. This is the clinical appearance before Mohs surgery (A) and after clearance of the tumor (B). JAAD Case Reports 2016 2, 47-50DOI: (10.1016/j.jdcr.2015.12.003) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions