Vinod H. Thourani, MD, Hanna A

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Outcomes in Nonagenarians Undergoing Transcatheter Aortic Valve Replacement in the PARTNER-I Trial Vinod H. Thourani, MD, Hanna A. Jensen, MD, PhD, Vasilis Babaliaros, MD, Susheel K. Kodali, MD, Jeevanantham Rajeswaran, PhD, John Ehrlinger, PhD, Eugene H. Blackstone, MD, Rakesh M. Suri, MD, Creighton W. Don, MD, PhD, Gabriel Aldea, MD, Mathew R. Williams, MD, Raj Makkar, MD, Lars G. Svensson, MD, PhD, James M. McCabe, MD, Larry S. Dean, MD, Samir Kapadia, MD, David J. Cohen, MD, Augusto D. Pichard, MD, Wilson Y. Szeto, MD, Howard C. Herrmann, MD, Chandan Devireddy, MD, Bradley G. Leshnower, MD, Gorav Ailawadi, MD, Hersh S. Maniar, MD, Rebecca T. Hahn, MD, Martin B. Leon, MD, Michael Mack, MD The Annals of Thoracic Surgery Volume 100, Issue 3, Pages 785-793 (September 2015) DOI: 10.1016/j.athoracsur.2015.05.021 Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Age distributions of study cohorts (% in each year). (A) Transfemoral transcatheter aortic valve replacement (TF-TAVR). (B) Transapical transcatheter aortic valve replacement (TA-TAVR). The Annals of Thoracic Surgery 2015 100, 785-793DOI: (10.1016/j.athoracsur.2015.05.021) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Prosthetic valve hemodynamics after transcatheter aortic valve replacement (TAVR). (A) Box-and-whiskers plots depicting the distribution of transvalvular aortic mean gradient at discharge, 30 days, and 6 months after transfemoral (TF)-TAVR. Horizontal bars within the boxes indicate median; top and bottom of the boxes indicate 75th and 25th percentiles. Whiskers extend to 1.5 times the interquartile range. (B) Percent of TF-TAVR patients in each paravalvular leak grade at discharge, 30 days, and 6 months. (C) Box-and-whiskers plots depicting the distribution of transvalvular aortic mean gradient at discharge, 30 days, and 6 months after transapical (TA)-TAVR. Format is as in (A). (D) Percent of TA-TAVR patients in each paravalvular leak grade at discharge, 30 days, and 6 months. The Annals of Thoracic Surgery 2015 100, 785-793DOI: (10.1016/j.athoracsur.2015.05.021) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Functional health status and quality of life after transcatheter aortic valve replacement (TAVR). (A) Percent of transfemoral (TF)-TAVR patients in each New York Heart Association (NYHA) functional class at discharge, 30 days, and 6 months. (B) Quality of life measures at baseline, then 1 month, 6 months, and 1 year after TF-TAVR. Horizontal bars within the boxes indicate median; top and bottom of the boxes indicate 75th and 25th percentiles. Whiskers extend to 1.5 times the interquartile range. Outliers beyond the whiskers are plotted as points. (C) Percent of transapical (TA)-TAVR patients in each New York Heart Association (NYHA) functional class at discharge, 30 days, and 6 months. (D) Quality of life measures at baseline, then 1 month, 6 months, and 1 year after TA-TAVR. Format is as in (B). The Annals of Thoracic Surgery 2015 100, 785-793DOI: (10.1016/j.athoracsur.2015.05.021) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Stroke after transcatheter aortic valve replacement (TAVR) stratified by transfemoral (TF)-TAVR versus transapical (TA)-TAVR. Each symbol represents a stroke. Vertical bars are confidence intervals of Kaplan-Meier estimates equivalent to ±1 standard error and solid lines enclosed within dashed 68% confidence bands equivalent to ±1 standard error represent parametric estimates. Numbers below the x axis are patients at risk. The Annals of Thoracic Surgery 2015 100, 785-793DOI: (10.1016/j.athoracsur.2015.05.021) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Death after transcatheter aortic valve replacement (TAVR) stratified by transfemoral (TF)-TAVR versus transapical (TA)-TAVR, referenced to that expected in an age-sex-race–matched US population (– • – lines). Each symbol represents a death. Vertical bars are confidence intervals of Kaplan-Meier estimates equivalent to ±1 standard error and solid lines enclosed within dashed 68% confidence bands equivalent to ±1 standard error represent parametric estimates. Numbers below the x axis are patients at risk. The Annals of Thoracic Surgery 2015 100, 785-793DOI: (10.1016/j.athoracsur.2015.05.021) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig E1A The Annals of Thoracic Surgery 2015 100, 785-793DOI: (10.1016/j.athoracsur.2015.05.021) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig E1B The Annals of Thoracic Surgery 2015 100, 785-793DOI: (10.1016/j.athoracsur.2015.05.021) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig E2A The Annals of Thoracic Surgery 2015 100, 785-793DOI: (10.1016/j.athoracsur.2015.05.021) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig E2B The Annals of Thoracic Surgery 2015 100, 785-793DOI: (10.1016/j.athoracsur.2015.05.021) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig E3A The Annals of Thoracic Surgery 2015 100, 785-793DOI: (10.1016/j.athoracsur.2015.05.021) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig E3B The Annals of Thoracic Surgery 2015 100, 785-793DOI: (10.1016/j.athoracsur.2015.05.021) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig E4A The Annals of Thoracic Surgery 2015 100, 785-793DOI: (10.1016/j.athoracsur.2015.05.021) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig E4B The Annals of Thoracic Surgery 2015 100, 785-793DOI: (10.1016/j.athoracsur.2015.05.021) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions