A novel classification for IgA nephropathy Ryohei Yamamoto, Enyu Imai  Kidney International  Volume 76, Issue 5, Pages 477-480 (September 2009) DOI: 10.1038/ki.2009.206 Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 1 Strategy to develop the Oxford classification of IgA nephropathy. The Oxford classification was developed in two steps from 265 cases of IgA nephropathy with proteinuria greater than 0.5g/d and estimated glomerular filtration rate (eGFR) at least 30ml/min/1.73m2, followed for at least 1 year. First, to create the reproducible classification, the group refined the pathological scoring system by evaluating 265 renal biopsy samples from eight countries. Intraclass correlation coefficients were used for evaluation of the reproducibility of the scoring system. Seven pathological lesions were highly reproducible and can be used for classification of IgA nephropathy. Second, the pathological findings that represented independent risk factors for progression of IgA nephropathy were analyzed by multivariate models. *Excluded in the subsequent analyses because of high correlation coefficient with interstitial fibrosis/tubular atrophy and susceptibility to sampling error. **Endocapillary proliferative lesions were not significantly predictive of the rate of eGFR decline or of a 50% decrease in eGFR/ESRD. ESRD, end-stage renal disease. Kidney International 2009 76, 477-480DOI: (10.1038/ki.2009.206) Copyright © 2009 International Society of Nephrology Terms and Conditions