Fig. 2. Binding of recombinant full-length Lm-411 to muscle receptors, myotubes, and self-polymerization is enhanced by mag and αLNNd. Binding of recombinant.

Slides:

Advertisements

Similar presentations

Fig. 1 CSF1 is increased in blood of melanoma patients and correlates with disease progression. CSF1 is increased in blood of melanoma patients and correlates.

Advertisements

Fig. 6. Transgenic expression of αLNNd and mag in dyW/dyW mice improves muscle function, increases body weight, and prolongs life span. Transgenic expression.

Fig. 4. Primary human metastatic melanomas contain CCL21-expressing LECs, and expression of VEGFC positively correlates with hallmarks of tumor inflammation.

Fig. 3. Ultrasound-mediated BMP-6 gene delivery to mini-pig tibial bone fractures. Ultrasound-mediated BMP-6 gene delivery to mini-pig tibial bone fractures.

Fig. 1. Generation of ERY974. Generation of ERY974. (A) Schematic illustration of ERY974 structure and the introduced mutations. The two Fab arms share.

Fig. 6. dAST directly from clinical samples using dPCR and dLAMP for quantification. dAST directly from clinical samples using dPCR and dLAMP for quantification.

Fig. 3. Cytokines trigger proliferation and block differentiation of perivascular adipocytes. Cytokines trigger proliferation and block differentiation.

Fig. 5. Circulating PPi concentration does not correlate with severity of calcification phenotype in mice. Circulating PPi concentration does not correlate.

Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.

Fig. 4. Bexarotene promotes PPARδ activation of target genes in mouse brain and muscle. Bexarotene promotes PPARδ activation of target genes in mouse brain.

Fig. 1. BCAS1 expression identifies newly generated oligodendrocytes.

Fig. 3. LTB4 exhibits concentration-dependent effects on HLEC lymphangiogenesis and survival. LTB4 exhibits concentration-dependent effects on HLEC lymphangiogenesis.

Fig. 4. Biomechanical properties of treated tibiae.

Fig. 4. aPD-1 mAb transfer to macrophages is mediated by FcγRs.

Analysis of brain and spinal cord of treated Gaa−/− mice and controls

Fig. 3. BET inhibition reduces homologous recombination.

Fig. 6 Bimodal treatment results in reduced tinnitus loudness and reduced TFI scores in human patients. Bimodal treatment results in reduced tinnitus loudness.

Fig. 3. A circadian rhythm in fibroblast wound-healing response.

MRSA virulence proteins cause LMC death and diminished CLV function

Fig. 1 MT-2 ameliorates asthmatic pulmonary resistance.

Fig. 1 DMF promotes viral infection.

Fig. 4 Infection-induced CLV dysfunction is associated with decreased LMC coverage. Infection-induced CLV dysfunction is associated with decreased LMC.

Fig. 2. GPC3 expression in normal and tumor tissues.

Bio-AMS enhances the activity of rifampicin and ethambutol in vitro

Fig. 2 Crystal structures and mannose binding of FimH variants in a tip-like setting. Crystal structures and mannose binding of FimH variants in a tip-like.

Increased ADMA in pregnancy is associated with SGA birth outcomes

Fig. 5. Remnants of PS+ platelets induce neutrophil macroaggregation.

Fig. 7 Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors. Gel scaffold for inhibition of postsurgical recurrence of B16F10 tumors.

Fig. 1. Muscles of LAMA2 MD patients and dyW/dyW mice contain high amounts of laminin-α4 and show deficits in BM. Muscles of LAMA2 MD patients and dyW/dyW.

Fig. 4 Nanocages captured multiple TB-related analytes.

Fig. 4. Expression of HGF in liver ECs cooperates with NOX4 inhibition to enhance engraftment of regenerative hepatocytes. Expression of HGF in liver ECs.

Fig. 4. Actin polymerization rhythms are required for circadian regulation of adhesion and wound-healing efficacy by fibroblasts. Actin polymerization.

Fig. 2. Circulating VEGF in GCA patients up-regulates microvascular endothelial Jagged1. Circulating VEGF in GCA patients up-regulates microvascular endothelial.

Fig. 1. mGlu7 expression is reduced in RTT autopsy samples.

Fig. 1. Neurobehavioral testing in YG8R mice transplanted with wild-type mouse HSPCs. Neurobehavioral testing in YG8R mice transplanted with wild-type.

Cohesin-loader−stimulated cohesin loading.

Workflow of a sample-to-answer AST performed in less than 30 min

Nec‐1 inhibits the phosphorylation and aggregation of tau

Fig. 7. Inhibitory mechanisms of C12G6.

Fig. 4. Identification of GRP78 as the target antigen of NMO-rAbs ON and ON Identification of GRP78 as the target antigen of NMO-rAbs.

Fig. 5 Local gel scaffold for T cell memory response.

Lnp protein requires phospholipids to form stacked discs.

Fig. 7 Improvement of clinical score and axon pathology by nasal IL-4 treatment during chronic EAE. Improvement of clinical score and axon pathology by.

Fig. 7 CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα. CSPG4-high GBMs show more microglia than CSPG4-low GBMs and express TNFα.

Fig. 1. Thorase variants show defects in Thorase oligomer and GluA2-GRIP1 complex disassembly. Thorase variants show defects in Thorase oligomer and GluA2-GRIP1.

Fig. 1. β-APP overexpression or exposure to inflammatory mediators induces sIBM-like pathology in cultured rat myocytes that is abrogated by arimoclomol.

Fig. 3. Morphological changes associated with glial activation were reduced in 16-month-old APP/PS1;C3 KO mice. Morphological changes associated with glial.

Kurt W. Prins et al. BTS 2016;1: T-Tubule Derangements in mdx Mice Are Associated With JPH-2 Misregulation (A) Representative confocal images of.

Fig. 2. IL-2/rapamycin–expanded T cells express homing receptors to traffic to lymphoma sites and are resistant to SN-38 toxicity. IL-2/rapamycin–expanded.

Fig. 3. VEGFR-3 signaling increases infiltration of naïve T cells in a CCR7-dependent manner. VEGFR-3 signaling increases infiltration of naïve T cells.

Fig. 2. CD31 provides robust NP targeting in vitro but slow kinetics.

Fig. 1 CSPG4 is expressed in GBM specimens and GBM-NS and associated with more aggressive disease. CSPG4 is expressed in GBM specimens and GBM-NS and associated.

Fig. 3 CSF1 is expressed in human melanoma.

Fig. 5 DMN-Tre labeling is selective for live mycobacteria.

Fig. 2 LAEs are characterized by vascular dysfunction, loss of endothelial perfusion and permeability, and perivascular hypoxia. LAEs are characterized.

Fig. 2. Cellular response to FolamiRs in vitro.

Fig. 1. Specificity of FolamiR uptake in cancer cells in culture.

LGN Blocks the Ability of NuMA to Bind and Stabilize Microtubules

Fig. 2. Thorase variants cause impaired GluA2 endocytosis and trafficking in mouse primary cortical neurons. Thorase variants cause impaired GluA2 endocytosis.

Fig. 2. BET inhibition enhances PARPi-induced DNA damage.

Binding of recombinant laminin-111, laminin-511, and their EQ mutants to integrins. Binding of recombinant laminin-111, laminin-511, and their EQ mutants.

Recombinant laminins used for in vitro binding assay.

The effects of KY19382 on chondrocyte proliferation and differentiation. The effects of KY19382 on chondrocyte proliferation and differentiation. (A) ATDC5.

Adenosine-induced osteogenic differentiation of hiPSCs involves A2bR

Interaction of periostin with ECM molecules.

Volume 16, Issue 4, Pages (April 1996)

Fig. 2 ODN enhances EV transfer between cells expressing TLR9.

by Judith R. Reinhard, Shuo Lin, Karen K

Fig. 5 Increased myometrial cell contractility in response to fetal T cells from preterm infants. Increased myometrial cell contractility in response to.

Fig. 5 Dcr-2 directly binds to Toll 3′UTR.

Presentation transcript:

Fig. 2. Binding of recombinant full-length Lm-411 to muscle receptors, myotubes, and self-polymerization is enhanced by mag and αLNNd. Binding of recombinant full-length Lm-411 to muscle receptors, myotubes, and self-polymerization is enhanced by mag and αLNNd. (A) Schematic of Lm-111, Lm-211, and Lm-411 and the linker molecules mag and αLNNd. Binding interactions of mag, αLNNd, laminins, integrins, and dystroglycan are indicated. (B) Binding curves of integrin α7X2β1 to Lm-111 and Lm-411. (C) Binding curves of Lm-111 and Lm-411 to purified αDG. (D) Binding curves of Lm-411 and Lm-411 plus an equimolar concentration of mag to purified αDG. Data in (B) to (D) are means ± SEM with n = 3 per condition. Curve fitting used the equation Y = Bmax*X/(Kd + X). (E) Polymerization assay for Lm-111, Lm-411, and an equimolar mixture of Lm-411 and αLNNd. Polymer formation was monitored by SDS–polyacrylamide gel electrophoresis (PAGE) and Coomassie blue staining after centrifugation. r2 = 0.998 (Lm-111), r2 = 0.941 (Lm-411 and αLNNd), and r2 = 0.0013 (Lm-411) using linear regression. (F) Confluent layer of cultured C2C12 myotubes after incubation with no Lm, recombinant Lm-211, Lm-411, or Lm-411 in the presence of an equimolar concentration of αLNNd and/or mag. C2C12-bound Lm-211 or Lm-411 was visualized by staining with antibodies to laminin-γ1. Representative immunofluorescence images (left) and quantification (right) of laminin-γ1 immunofluorescence (IF). Scale bar, 200 μm. n = 9 cultures (Lm-411 and mag), n = 6 cultures (Lm-411, Lm-411 + αLNNd, Lm-411 + αLNNd + mag, and Lm-211). Data are means ± SEM. ***P < 0.001; n.s., P > 0.05 (for exact P values, see table S3), one-way analysis of variance (ANOVA) with Bonferroni post hoc test. Judith R. Reinhard et al., Sci Transl Med 2017;9:eaal4649 Published by AAAS