Activation of the peroxynitrite-poly(adenosine diphosphate-ribose) polymerase pathway during neointima proliferation: A new target to prevent restenosis.

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Activation of the peroxynitrite-poly(adenosine diphosphate-ribose) polymerase pathway during neointima proliferation: A new target to prevent restenosis after endarterectomy Carsten J. Beller, MD, Tamás Radovits, MD, Jens Kosse, MD, Domokos Gerö, MD, Csaba Szabó, MD, PhD, Gábor Szabó, MD, PhD Journal of Vascular Surgery Volume 43, Issue 4, Pages 824-830 (April 2006) DOI: 10.1016/j.jvs.2005.11.021 Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 1 Morphometric results and representative histologic cross-sections of the different treatment groups (hematoxylin-eosin). A, Neointima/media thickness ratio in the different groups. Values are expressed as mean ± SD. ⁎P < .05 vs sham; †P < .05 vs control. B, Sham group. C, Control group with massive neointima proliferation. D, Significantly less neointima formation after treatment with INO-1001. Journal of Vascular Surgery 2006 43, 824-830DOI: (10.1016/j.jvs.2005.11.021) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 2 Histologic scores for nitrotyrosine (NT), poly(adenosine diphosphate-ribose) (PAR), and nuclear activity of apoptosis-inducing factor (AIF) in the different wall layers of sham, control and INO-1001 groups. Values are expressed as mean ± SD ⁎P < .05 vs sham, †P < .05 vs control. Journal of Vascular Surgery 2006 43, 824-830DOI: (10.1016/j.jvs.2005.11.021) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 3 Representative stainings for nitrotyrosine (NT, brown), poly(adenosine diphosphate-ribose) (PAR, black), and nuclear translocation of apoptosis-inducing factor (AIF, dark blue/black) in sham, control and INO-1001 treated animals. NT staining was found primarily in the cytosol of the neointima in the control group, whereas PAR staining was present predominantly in the cell nuclei. AIF staining was present as well predominantly in the cell nuclei as a result of translocation, nevertheless residual staining in the cytosol can be observed. After INO-1001 treatment, NT, PAR and nuclear AIF immunoreactivity was nearly absent. Journal of Vascular Surgery 2006 43, 824-830DOI: (10.1016/j.jvs.2005.11.021) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions