Efficacy of a new coating material, PMEA, for cardiopulmonary bypass circuits in a porcine model Hitoshi Suhara, MD, Yoshiki Sawa, MD, Motonobu Nishimura,

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Efficacy of a new coating material, PMEA, for cardiopulmonary bypass circuits in a porcine model Hitoshi Suhara, MD, Yoshiki Sawa, MD, Motonobu Nishimura, MD, Hiroaki Oshiyama, Kenji Yokoyama, Noboru Saito, Hikaru Matsuda, MD The Annals of Thoracic Surgery Volume 71, Issue 5, Pages 1603-1608 (May 2001) DOI: 10.1016/S0003-4975(01)02466-3 Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Changes in platelet counts during cardiopulmonary bypass (CPB). The ratios of values to precounts are shown. The average values at 120 minutes of CPB were: group P, 101.4% ± 30.8%; group C, 59.56% ± 5.88%; group H, 86.1% ± 23.7%. †versus C, p < 0.001. (group P = PMEA-coated circuits; group C = noncoated circuits; group H = heparin-coated circuits; PMEA = poly-2-methoxyethyl acrylate; PRE = before CPB.) The Annals of Thoracic Surgery 2001 71, 1603-1608DOI: (10.1016/S0003-4975(01)02466-3) Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Changes in thrombin-antithrombin (TAT) complex levels during cardiopulmonary bypass (CPB). Suppression of the TAT complex was significant for the heparin- and PMEA-coating groups. TAT complex in the noncoated group peaked at 60 minutes of CPB. The average values at 60 minutes of CPB were: group P, 5.13 ± 2.60 pg/mL; group H, 11.5 ± 8.11 pg/mL; group C, 72.8 ± 5.88 pg/mL. †versus C, p < 0.001. (group P = PMEA-coated circuits; group C = noncoated control circuits; group H = heparin-coated circuits; PMEA = poly-2-methoxyethyl acrylate; PRE = before CPB.) The Annals of Thoracic Surgery 2001 71, 1603-1608DOI: (10.1016/S0003-4975(01)02466-3) Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Changes in bradykinin during cardiopulmonary bypass (CPB). Suppression of bradykinin was significant for the PMEA- and heparin-coated groups. At 120 minutes of CPB, the average values were: group P, 10.5 ± 0.48 pg/mL; group C, 42.5 ± 12.6 pg/mL; group H, 14.1 ± 2.77 pg/mL; P versus C, p < 0.005. †versus C, p < 0.05. (group P = PMEA-coated circuits; group C = noncoated control circuits; group H = heparin-coated circuits; PMEA = poly-2-methoxyethyl acrylate; PRE = before CPB.) The Annals of Thoracic Surgery 2001 71, 1603-1608DOI: (10.1016/S0003-4975(01)02466-3) Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Electron micrographs of the oxygenator after bypass. (A) no coating, (B) heparin coating, and (C) poly-2-methoxyethyl acrylate (PMEA) coating. Thrombus formation was observed in the no-coating group (A), but almost no adherent thrombi were observed in the PMEA- and heparin-coating groups (B, C). The Annals of Thoracic Surgery 2001 71, 1603-1608DOI: (10.1016/S0003-4975(01)02466-3) Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Immunoblot with antipig fibrinogen of an electrophorogram of eluted protein from the oxygenators of groups with no coating, heparin coating, and poly-2-methoxyethyl acrylate (PMEA) coating. (Band α, 68 kDa; β, 55 kDa; γ, 47 kDa, α′, 25 kDa; β′, 44 kDa, γ′, 42 kDa.) The Annals of Thoracic Surgery 2001 71, 1603-1608DOI: (10.1016/S0003-4975(01)02466-3) Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions