Do Flies Count Sheep or NMDA Receptors to Go to Sleep?

Slides:

Advertisements

Similar presentations

The Bacterial DnaC Helicase Loader Is a DnaB Ring Breaker Ernesto Arias-Palomo, Valerie L. O’Shea, Iris V. Hood, James M. Berger Cell Volume 153, Issue.

Advertisements

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

The RAG Recombinase Dictates Functional Heterogeneity and Cellular Fitness in Natural Killer Cells Jenny M. Karo, David G. Schatz, Joseph C. Sun Cell Volume.

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity Jenni Durieux, Suzanne Wolff, Andrew Dillin Cell Volume 144, Issue 1, Pages.

Local Translation of Extranuclear Lamin B Promotes Axon Maintenance Byung C. Yoon, Hosung Jung, Asha Dwivedy, Catherine M. O'Hare, Krishna H. Zivraj, Christine.

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:

Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding J. Winter, M. Ilbert, P.C.F. Graf, D. Özcelik, U. Jakob Cell Volume 135, Issue.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.

NMDA Receptors in Dopaminergic Neurons Are Crucial for Habit Learning Lei Phillip Wang, Fei Li, Dong Wang, Kun Xie, Deheng Wang, Xiaoming Shen, Joe Z.

Common Sense about Taste: From Mammals to Insects David A. Yarmolinsky, Charles S. Zuker, Nicholas J.P. Ryba Cell Volume 139, Issue 2, Pages (October.

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke Jae Young Lee, Wei Yang Cell Volume 127, Issue 7, Pages (December.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron

Nucleation and Transport Organize Microtubules in Metaphase Spindles Jan Brugués, Valeria Nuzzo, Eric Mazur, Daniel J. Needleman Cell Volume 149, Issue.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages (June 2006) DOI: /j.neuron

AMPA Receptor Signaling through BRAG2 and Arf6 Critical for Long-Term Synaptic Depression Ralf Scholz, Sven Berberich, Louisa Rathgeber, Alexander Kolleker,

Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.

Dynein Anchors Its mRNA Cargo after Apical Transport in the Drosophila Blastoderm Embryo Renald Delanoue, Ilan Davis Cell Volume 122, Issue 1, Pages

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

Transmembrane Receptor DCC Associates with Protein Synthesis Machinery and Regulates Translation Joseph Tcherkezian, Perry A. Brittis, Franziska Thomas,

The Landscape of Microsatellite Instability in Colorectal and Endometrial Cancer Genomes Tae-Min Kim, Peter W. Laird, Peter J. Park Cell Volume 155, Issue.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.

Pulsed Forces Timed by a Ratchet-like Mechanism Drive Directed Tissue Movement during Dorsal Closure Jerome Solon, Aynur Kaya-Çopur, Julien Colombelli,

SRC-3 Coactivator Functional Lifetime Is Regulated by a Phospho-Dependent Ubiquitin Time Clock Ray-Chang Wu, Qin Feng, David M. Lonard, Bert W. O'Malley.

Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages (February 2008) DOI: /j.neuron

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens Rafael de Cabo, Didac Carmona-Gutierrez, Michel Bernier, Michael N. Hall, Frank.

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Volume 58, Issue 5, Pages (June 2015)

Protein Networks in Alzheimer’s Disease

Unweaving the Autism Spectrum

Chinmo and Neuroblast Temporal Identity

In This Issue Cell Volume 158, Issue 5, (August 2014)

Volume 129, Issue 4, Pages (May 2007)

Multimodal Signal Integration for Feeding Control

Monkey Research in China: Developing a Natural Resource

Myosin Learns to Recruit AMPA Receptors

Synaptic Plasticity of Feeding Circuits: Hormones and Hysteresis

Volume 152, Issue 1, (January 2013)

Monkey Research in China: Developing a Natural Resource

Volume 130, Issue 6, (September 2007)

In and out of the Replication Factory

A Molecular Link Tethering Neuronal Responses with the Past

Watching the Fly Brain Learn

Volume 91, Issue 6, Pages (September 2016)

Volume 143, Issue 6, (December 2010)

Boning up on Ephrin Signaling

Location, Location, Location: Contrasting Roles of Synaptic and Extrasynaptic NMDA Receptors in Huntington's Disease Michael S. Levine, Carlos Cepeda,

Volume 166, Issue 4, Pages (August 2016)

Making the Most from Changes in Life

Cortical Cliques: A Few Plastic Neurons Get All the Action

The Plasticity of Aging: Insights from Long-Lived Mutants

Learning from the Uncontrollable

SCOPing out Proteases in Long-Term Memory

Finding the Roots of Adult Neurogenesis

Volume 163, Issue 4, (November 2015)

Anatomical Plasticity of Adult Brain Is Titrated by Nogo Receptor 1

The Cost of Brain Diseases: A Burden or a Challenge?

Volume 163, Issue 2, (October 2015)

SCOPing out Proteases in Long-Term Memory

Flies Sleep on It, or Fuhgeddaboudit!

LUSH Shapes Up for a Starring Role in Olfaction

Volume 134, Issue 6, (September 2008)

David Hubel and Torsten Wiesel

In This Issue Cell Volume 145, Issue 3, (April 2011)

Volume 148, Issue 1, (January 2012)

Presentation transcript:

Do Flies Count Sheep or NMDA Receptors to Go to Sleep? Seana Lymer, Justin Blau Cell Volume 165, Issue 6, Pages 1310-1311 (June 2016) DOI: 10.1016/j.cell.2016.05.059 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 R2 Ring Neurons Function in Drosophila Sleep Homeostasis Time spent awake and sleep deprivation cause intracellular Ca2+ levels and NMDA receptor abundance to rise in R2 ring neurons in the Drosophila central brain. This increases the number and size of R2 neuron pre-synaptic active zones and R2 firing rates, which promote sleep (top). These changes are plastic: sleep reverses these changes in R2 ring neurons to reduce sleep drive (bottom). Cell 2016 165, 1310-1311DOI: (10.1016/j.cell.2016.05.059) Copyright © 2016 Elsevier Inc. Terms and Conditions