Stefano Toldo et al. BTS 2017;2:

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Stefano Toldo et al. BTS 2017;2:561-574 LRP1 Mediates SP16-Induced Cardioprotection We pretreated mice with a Low-density lipoprotein receptor–related protein-1 (LRP1) blocking antibody to test whether LRP1 mediated the cardioprotective signal of SP16 and alpha-1 antitrypsins (AAT). Treatment with the blocking antibody eliminated the protective effects of both SP16 and plasma-derived AAT. n = 5 to 8 mice/group. Ab = antibody; LV = left ventricular. Stefano Toldo et al. BTS 2017;2:561-574 2017 The Authors