Volume 393, Issue 10180, Pages (April 2019)

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Volume 393, Issue 10180, Pages 1517-1526 (April 2019) Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomised trial Prof Brian D Foy, PhD, Haoues Alout, PhD, Jonathan A Seaman, BSc, Sangeeta Rao, PhD, Tereza Magalhaes, PhD, Martina Wade, BSc, Sunil Parikh, MD, Dieudonné D Soma, MS, André B Sagna, PhD, Florence Fournet, PhD, Hannah C Slater, PhD, Roland Bougma, MS, François Drabo, MD, Abdoulaye Diabaté, PhD, A Gafar V Coulidiaty, MD, Nöel Rouamba, MD, Prof Roch K Dabiré, PhD The Lancet Volume 393, Issue 10180, Pages 1517-1526 (April 2019) DOI: 10.1016/S0140-6736(18)32321-3 Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 1 Trial profile Children refers to those aged 5 years or younger, in whom the primary outcome (malaria incidence) was assessed. The Lancet 2019 393, 1517-1526DOI: (10.1016/S0140-6736(18)32321-3) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 2 Rainfall and weekly malaria incidence per person-year in children aged 5 years or younger over the study period Incidence data are shown with 95% CIs (error bars). Rainfall is shown in blue. The times of each MDA are denoted below the graph and with vertical lines. MDA=mass drug administration. The Lancet 2019 393, 1517-1526DOI: (10.1016/S0140-6736(18)32321-3) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 3 Frequency distribution of malaria episodes in children aged 5 years or younger Children were grouped by the number of malaria episodes (zero to seven) that they had within the 18-week intervention period. Bars show proportion of children from each group that fell into each malaria episode frequency category (n=327 in the intervention group; n=263 in the control group). The Lancet 2019 393, 1517-1526DOI: (10.1016/S0140-6736(18)32321-3) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 4 Kaplan-Meier plot of time to first malaria episode in cohort children over the study period Upticks designate censored data. Analysis was adjusted for the clustering effects of household. The Lancet 2019 393, 1517-1526DOI: (10.1016/S0140-6736(18)32321-3) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions