A relationship between mechanically-induced changes in serum cartilage oligomeric matrix protein (COMP) and changes in cartilage thickness after 5 years

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A relationship between mechanically-induced changes in serum cartilage oligomeric matrix protein (COMP) and changes in cartilage thickness after 5 years J.C. Erhart-Hledik, J. Favre, J.L. Asay, R.L. Smith, N.J. Giori, A. Mündermann, T.P. Andriacchi Osteoarthritis and Cartilage Volume 20, Issue 11, Pages 1309-1315 (November 2012) DOI: 10.1016/j.joca.2012.07.018 Copyright © 2012 Terms and Conditions

Fig. 1 Analyzed medial (A) femoral and (B) tibial sub-regions. iM: internal, cM: central, eM: external, aM: anterior, pM: posterior. Osteoarthritis and Cartilage 2012 20, 1309-1315DOI: (10.1016/j.joca.2012.07.018) Copyright © 2012 Terms and Conditions

Fig. 2 Baseline protocol. The vertical arrows indicate blood draws and the number at the bottom indicates hour of the testing day. Osteoarthritis and Cartilage 2012 20, 1309-1315DOI: (10.1016/j.joca.2012.07.018) Copyright © 2012 Terms and Conditions

Fig. 3 Serum COMP concentrations in percent of baseline after a 30-min exercise activity. (A) Each line represents an individual patient. (B) Average serum COMP concentration for all subjects. * Indicates significant difference vs pre-activity level (P<0.05). Osteoarthritis and Cartilage 2012 20, 1309-1315DOI: (10.1016/j.joca.2012.07.018) Copyright © 2012 Terms and Conditions

Fig. 4 Association between change in COMP concentration (3.5h post-activity) and 5-year change in cartilage thickness for the anterior medial tibia. Osteoarthritis and Cartilage 2012 20, 1309-1315DOI: (10.1016/j.joca.2012.07.018) Copyright © 2012 Terms and Conditions