del Nido versus Buckberg cardioplegia in adult isolated valve surgery

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del Nido versus Buckberg cardioplegia in adult isolated valve surgery Stephanie L. Mick, MD, Michael P. Robich, MD, MSPH, Penny L. Houghtaling, MS, A. Marc Gillinov, MD, Edward G. Soltesz, MD, MPH, Douglas R. Johnston, MD, Eugene H. Blackstone, MD, Joseph F. Sabik, MD The Journal of Thoracic and Cardiovascular Surgery Volume 149, Issue 2, Pages 626-636.e5 (February 2015) DOI: 10.1016/j.jtcvs.2014.10.085 Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Highest measured troponin T levels after isolated AV and MV surgery: (A) after AV surgery, unmatched patients; (B) after AV surgery, propensity-matched patients; (C) after MV surgery, unmatched patients; (D) after MV surgery, propensity-matched patients. Solid lines represent patients receiving del Nido solution; dashed lines represent those receiving Buckberg solution. AV, Aortic valve; MV, mitral valve. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 626-636.e5DOI: (10.1016/j.jtcvs.2014.10.085) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Relationship of troponin T level to myocardial ischemic time. Filled circles represent values for del Nido patients; open squares represent values for Buckberg patients. Solid lines are regression estimates (Table E4). A, Patients undergoing primary isolated aortic valve operations. B, Patients undergoing primary isolated mitral valve operations. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 626-636.e5DOI: (10.1016/j.jtcvs.2014.10.085) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 Mirrored histogram of distribution of propensity scores. Darkened areas represent matched patient pairs: (A) isolated aortic valve surgery; (B) isolated mitral valve surgery. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 626-636.e5DOI: (10.1016/j.jtcvs.2014.10.085) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

Figure E2 Propensity-score matching for del Nido versus Buckberg solution in adult isolated valve surgery. A, Covariable balance for selected variables before (triangles) and after (squares) propensity matching, expressed as standardized difference: aortic valve surgery. B, Covariable balance for selected variables before (triangles) and after (squares) propensity matching, expressed as standardized difference: mitral valve surgery. AV, Aortic valve; COPD, chronic obstructive pulmonary disease; AVR, aortic valve replacement; NYHA, New York Heart Association; Clr, clearance; LVEF, left ventricular ejection fraction; PAD, peripheral arterial disease; BC, Buckberg solution; DNS, del Nido solution; TV regurg, tricuspid valve regurgitation; MVR, mitral valve replacement; LA, left atrial. The Journal of Thoracic and Cardiovascular Surgery 2015 149, 626-636.e5DOI: (10.1016/j.jtcvs.2014.10.085) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions