Human bocavirus 1 may suppress rhinovirus-associated immune response in wheezing children Heikki Lukkarinen, MD, Maria Söderlund-Venermo, PhD, Tytti.

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Human bocavirus 1 may suppress rhinovirus-associated immune response in wheezing children Heikki Lukkarinen, MD, Maria Söderlund-Venermo, PhD, Tytti Vuorinen, MD, Tobias Allander, MD, Klaus Hedman, MD, Olli Simell, MD, Olli Ruuskanen, MD, Tuomas Jartti, MD Journal of Allergy and Clinical Immunology Volume 133, Issue 1, Pages 256-258.e4 (January 2014) DOI: 10.1016/j.jaci.2013.10.014 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Cytokine responses in wheezing associated with RV, HBoV1, and combined RV-HBoV1 in young children. The data are expressed as median (interquartile range) and analyzed by 1-way ANOVA and Tukey post hoc comparison. *P < .05 vs the RV group. Journal of Allergy and Clinical Immunology 2014 133, 256-258.e4DOI: (10.1016/j.jaci.2013.10.014) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Incidence of recurrent wheezing in young children with RV (n = 16), HBoV1 (n = 11) and combined RV-HBoV1 (n = 11)-associated wheezing. The data are expressed as percentage of children with recurrent wheezing after the study entry. Data were analyzed by using the Log-rank test. Overall comparison, P = .10; RV vs RV-HBoV1, P = .07; RV vs HBoV1, P = .11. Journal of Allergy and Clinical Immunology 2014 133, 256-258.e4DOI: (10.1016/j.jaci.2013.10.014) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Study flow chart. ICU, Intensive care unit. Journal of Allergy and Clinical Immunology 2014 133, 256-258.e4DOI: (10.1016/j.jaci.2013.10.014) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions