Figure 2 Precision medicine — describing individuals

Slides:

Advertisements

Similar presentations

On Equity and Evidence in Precision Medicine Leila Jamal, ScM, CGC Research Assistant, Baylor College of Medicine PhD Candidate, Johns Hopkins University.

Advertisements

Ann Intern Med. 2014;160(11): doi: /M Figure Legend:

Nat. Rev. Cardiol. doi: /nrcardio

Whole Health Rx Pharmacy Search

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Figure 4 BMI and mortality in patients with heart failure

Nat. Rev. Cardiol. doi: /nrcardio

Figure 5 Two approaches to therapeutic genome editing

Figure 1 Evolution of genetic concepts underlying risk of cardiovascular disease Figure 1 | Evolution of genetic concepts underlying risk of cardiovascular.

Figure 1 Experimental design

Figure 1 Energy supply–demand matching in health and heart failure

Nat. Rev. Cardiol. doi: /nrcardio

Figure 3 Global rates of sodium, fruit, and vegetable intake

Figure 4 Precision prescribing

Nat. Rev. Cardiol. doi: /nrcardio

Figure 1 Metabolic profiling as a tool for studying rheumatic diseases

Figure 1 Proactive and reactive prevention of cardiovascular disease

Figure 3 Traditional geometry and spatial fractals

Figure 8 4D magnetic resonance imaging patterns

Figure 4 Doppler echocardiographic assessment

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Figure 3 Gut microbiome and natural killer T (NKT) cells

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Figure 1 Health-care system today

Nat. Rev. Cardiol. doi: /nrcardio

Figure 1 Cardiovascular risk and disease across the life-course

Nat. Rev. Cardiol. doi: /nrcardio

Figure 1 Decision tree integrating the assessment,

Nat. Rev. Cardiol. doi: /nrcardio

Figure 3 Neural crest cell migration

Figure 2 Global cost of HF per capita in 2012

Figure 5 Examples of biomarker-guided trials

Nat. Rev. Cardiol. doi: /nrcardio

Figure 1 Manual thrombus aspiration

Nat. Rev. Cardiol. doi: /nrcardio

Figure 1 Milestones in coronary angioplasty

Nat. Rev. Cardiol. doi: /nrcardio

Figure 3 Challenges for big data applications in cardiovascular care

Volume 25, Issue 3, Pages (March 2017)

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Figure 3 Effects of cardiovascular medication on the fetus

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Figure 1 Essential features and goals of a precision medicine system

Figure 5 Systems biological model of IBS

Nat. Rev. Cardiol. doi: /nrcardio

Figure 2 Sources of data to characterize the ADPKD clinical phenotype

Figure 3 Enrichment strategies for clinical trials

Nat. Rev. Cardiol. doi: /nrcardio

Figure 4 Electrocardiogram patterns associated with Brugada syndrome

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Figure 2 Impaired mitochondrial capacity and function in heart failure

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Figure 3 Matrix signals regulate valve cell phenotypes

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Figure 4 Radiogenomics analysis can reveal relationships

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Nat. Rev. Cardiol. doi: /nrcardio

Presentation transcript:

Figure 2 Precision medicine — describing individuals Figure 2 | Precision medicine — describing individuals. a | The six dimensions by which individuals might be described in the precision medicine era are the 'omic' data (such as the genomic and metabolomic phenotypes), data from health system registries (for example, electronic medical records, claims, and pharmacy registries), study-participant-generated data, the individual's motivations and behaviour, their microbiome, and their exposome and social determinants. These six factors interact with each other, producing a dynamic state. b | The precision participant descriptor integrates (and displays) the data from the six dimensions and is the phenotype of the individual. A dynamic cloud surrounds the phenotypic display to illustrate the changing nature of the phenotype as inputs (left side) vary over time. c | The electronic health-care system of the future will need to curate the data and display it in a user-friendly fashion to health-care providers at the point of care. Antman, E. M. & Loscalzo, J. (2016) Precision medicine in cardiology Nat. Rev. Cardiol. doi:10.1038/nrcardio.2016.101